Pharmaceutical Ointments in Pharmacy | 您所在的位置:网站首页 › ointmemts › Pharmaceutical Ointments in Pharmacy |
Table of Contents Topical Dosage Forms—Semisolids Conventional Topical Dosage Forms (Semisolids) includes OintmentsCreamsJelliesPastesOthers: Poultices (Cataplasms), Powders, Dressings, Plasters, nails etcOintmentsOintments as semisolid preparations intended for external application to the skin or mucous membranes for protection (calamine, ZnO, TiO2, Silicones) or emollient effect. In an ointment base, Medicament is dissolved, suspended or emulsified. Types of ointments:1. According to penetrationEpidermic ointment: These ointments are intended to produce their action on the surface of the skin and produce local effect,they are not absorbed. • They acts as protectives, antiseptics and parasiticides.Endodermic ointment: These ointments are intended to release the medicaments that penetrate into the skin. They are partially absorbed and acts as emollients, stimulants and local irritants.Diadermic ointment: These ointments are intended to release the medicaments that pass through the skin and produce systemic effects (absorb & produce systemic effect)2. According to therapeutic use:Antibiotic, Antifungal, Anti-inflammatory, Anti-pruritic, Counter irritant, keratolytic ointment etc 3. Type of ointmentsWater-soluble ointmentWater-insoluble ointment Types of ointment base:
The base should not produce irritation or sensitisation of the skin, nor should it retard wound healing; it should be smooth, inert, odourless or almost odourless, physically and chemically stable and compatible with the skin and with incorporated medicaments. .Four general classes of ointment bases: Ointments may contain suitable auxiliary substances such as antioxidants, stabilisers, thickeners and emulsifiers and, when the base might support the growth of microbial contaminants, suitable antimicrobial preservatives. ![]() Absorption bases are hydrophilic, anhydrous materials/substances or hydrous bases that have the ability to absorb additional water. (i) Anhydrous bases, which absorb water to become water-in-oil (W/O) emulsions; Hydrophilic petrolatum USP is an anhydrous absorption base . Its W/O emulsifying property is conferred by the inclusion of cholesterol.Eg. Wool fat (anhydroud lanolin), absorbed water 50 % of its wt (obtained wool of sheep)(ii) Hydrous base are W/O emulsions, which have the ability to absorb additional water Eg hydrous wool fat(lanolin) insoluble in water -30% water; Bee wax (white and yellow)- honeycomb of bee wax Absorption bases impart excellent emolliency and a degree of occlusiveness on application 3. Water–Removable (Water-Washable) Bases or emulsion base (O/W emulsion bases)most commonly used type of ointment base (creams are 0/w emulsion)Emulsion bases are washable and are removed easily from skin or clothing. Emulsion bases can be diluted with waterCream like consistencyPrepared from emulsifying wax, white soft paraffin & liquid paraffinVanishing cream is an o/w emulsion that contains a large percentage of water as well as a humectant (e.g., sorbitol, glycerin, or propylene glycol) that retards the surface evaporation of water. 4. Water–Soluble BasesWater-soluble bases are the polyethylene glycols (PEGs -carbowaxes)PEGs are relatively inert, nonvolatile, water-soluble or wate r-miscible liquidsPolyethylene glycol 400 is a liquid superficially similar to propylene glycol, while polyethylene glycol 6000 is a waxy solid.Tragacanth, gelatin, cellolose derivatives etc used as water soluble baseWater solubility of the polyethylene glycol bases may be attractive, but the glycol(s) may be irritating to traumatize d tissue S. NOOintment baseProperties Examples1Hydrocarbon (Oleaginous) BasesAnhydrous, Occlusive & Hydrophobic, greasy, Non-washableLiquid petrolatum(gelled by the addition of polyethylene) Vegetable fixed oils or animal fats Wax 2Absorption Bases i. Anhydrous base (w/o)absorb water to become water-in-oil (W/O) emulsionsHydrophilic petrolatum USP Wool fat (anhydrous lanolin)ii. Hydrous base (o/w)W/O emulsions, which have the ability to absorb additional waterhydrous wool fat(lanolin) Bee wax (white and yellow)3Water-Removable/Water-Washable Bases or emulsion base (O/W emulsion bases)washable and removed easily from skin or clothing & can dilute with WaterPrepared from emulsifying wax, white soft paraffin & liquid paraffin4Water-Soluble BasesPEG: Relatively inert, nonvolatile, water-soluble, or water-miscible liquidsCarbowaxes Tragacanth, gelatin, cellulose derivativesTypes of Ointments Bases Praparation of ointmentOintment preparation or manufacture depends on the type of vehicle and the quantity to be prepared. The main objective is to disperse/incorporation the drug uniformly throughout the base. 1. Incorporation of the drug by Trituration: The components of the ointment are mixed together by various means until a uniform preparation has been attained. – On a small scale, the pharmacist may mix the components of an ointment in a mortar with a pestle, or a spatula and an ointment slab may be used to rub the ingredients together. ![]() 2. Fusion: Highest MP –should be melted first to avoid overheating. By the fusion method, all or some of the components of an ointment are combined by being melted together and cooled with constant stirring until congealed. Those components not melted are generally added to the congealing mixture as it is being cooled and stirred. Naturally, heat-labile substances and any volatile components are added last when the temperature of the mixture is low enough not to cause decomposition of volatilization of the components. 3. Chemical reaction:- iodine ointment 4. Emulsification: heat base @70 degrees centigrade 5. Preparation of semi-solid/ointments at Industrial Triple roller millColloidal mill (mixing + size reduction both)Uses: Ointments are mainly used as propective or emollient action. Poultices (Cataplasms)Poultices, or cataplasms, represent one of the most ancient classes of pharmaceutical preparations. A poultice is a soft, moist mass of meal, herbs, seed, etc., usually applied hot in a cloth. The consistency is gruel-like, which is probably the origin of the word poultice.Cataplasms were intended to localize infectious material in the body or to act as counterirritants. The materials tended to be absorptive, which, together with heat, accounts for their popularity.Eg. Kaolin Poultice Evalaution of OintmentsUniformity of weight/ Content uniformity testPenetrationRate of release of DrugAbsorption of medicament into blood streamIrritant effectSpreadabilityJoin Our WhatsApp Group to receive the latest updates like Pharma Job notifications, study materials, admission alerts, Pharma News, etc WhatsAppJoin Our Telegram Group to receive the latest updates like Pharma Job notifications, study materials, admission alerts, Pharma News, etc TelegramJoin Our Telegram Group to Download Free Books & Notes, Previous papers for D.Pharm, B.Pharm, M.Pharm, Drug Inspector & GPAT………. TelegramShare:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)Like this:Like Loading...Related |
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