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Abstract: Objective：To investigate the clinical value and significance of high risk human papilloma virus（HPV）E6/E7 mRNA test in patients with HPV infection. Methods：Between January 2017 and June 2017，in Center of Diagnosis and Treatment for Cervical Disease，200 patients with HPV infection in cervical screening received high-risk HPV E6/E7 mRNA test and pathological biopsy under colposcopy. We analyzed the E6/E7 mRNA detection rate of positive cases，and the E6/E7mRNA expression in different pathological diagnosis. Results：The E6/E7 mRNA detection rate was 60% in the 200 patients. The highest E6/E7 mRNA positive expression in the high-grade squamous intraepithelial lesion group（HSIL）had significant differences with the low-grade squamous intraepithelial lesion group（LSIL）and the nomal group. The mRNA sensitivity was 97.9% and negative predictive value was 98.8%（P
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