聚乳酸纳米粒用于共同递送呋虫胺和阿维菌素对抗梨树害虫，提高有效期和增强生物活性,International Journal of Biological Macromolecules

防治病虫害的农药复配技术成为提高农药药效同时降低农药抗药性的有效途径。纳米材料和包封技术为制备高效农药制剂提供了新的视角，特别是构建用于增效农药的共递送纳米颗粒。本研究以聚乳酸（PLA）为壁材，采用双乳液法结合高压均质技术，构建了呋虫胺/阿维菌素共递送纳米颗粒（DACNPs）。DACNPs 的药物含量为 39.1%，平均粒径为 245.7 ± 4.2 nm，平均聚合物分散指数 (PDI) 值为 0.123。由于纳米级效应，DACNPs 在目标叶片上表现出高的叶面保留和良好的铺展性能。获得的 DACNPs 表现出较好的防治效果Grapholitha molesta Busck 和Psylla chinensis Yang et Li 与市售制剂相比，可显着延长药效，提高生物活性，且农药用量和使用频率较低。该研究可能为开发新型农药制剂以提高农药利用率、减少环境污染和降低农业成本提供新的见解。

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Pesticide compounding technology for disease and pest control emerges as an effective way to increase the effectiveness of pesticides while reducing pesticides resistance. Nanomaterials and encapsulation technology have offered a new insight into preparing efficient pesticide formulations, especially constructing a co-delivery nanoparticle for synergistic pesticides. In this study, a dinotefuran/avermectin co-delivery nanoparticles (DACNPs) against pear tree pests with polylactic acid (PLA) as the wall material were constructed by double-emulsion method combined with high-pressure homogenization technique. The drug content of the DACNPs was 39.1% with an average size of 245.7 ± 4.2 nm and the mean polymer dispersity index (PDI) value was 0.123. The DACNPs showed high foliar retention and good spread performance on target leaves due to the nanoscale effect. The obtained DACNPs showed a better control effect on Grapholitha molesta Busck and Psylla chinensis Yang et Li compared with the commercial formulations, which could significantly prolong the effective duration and enhance the bioactivity with lower amounts and application frequency of pesticides. This study may provide new insights into developing novel pesticide formulations to improve the utilization rate of pesticides, reduce environmental pollution and minimize the cost of farming.