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光子学报, 2022, 51 (5): 0551301, 网络出版: 2022-06-28 基于纳米光子学的手性检测与表征技术（特邀） 下载： 1054次Nanophotonic Methods for Chiral Sensing and Characterization（Invited）Get PDFFull Text图表MetricsMore 芮光浩 1,2詹其文 1,*
作者单位 1 上海理工大学 光电信息与工程学院，上海 2000932 东南大学 电子科学与工程学院 先进光子学中心，南京 210096
应用光学 纳米光子学 手性传感 圆二色性增强 光镊 Applied optics Nanophotonics Chirality sensing Enhanced circular dichroism Optical tweezers 摘要作为生物体的本质属性，物质的手性表征在生理学和药理学领域有着重要的意义。当电磁波与手性材料作用时，会出现旋光效应、圆二色性和手性光力等特殊的光学活性现象，并成为材料手性检测的强大工具。由于手性分子的结构远小于激发光的波长，因此分子自身的手性光学效应通常很弱，极大限制了检测技术的精度。近年来，纳米光子技术的进步有望增强纳米尺度下光与物质之间原本很弱的手性光学效应，使得手性的高灵敏度、高分辨率检测成为可能。回顾了手性光学的发展及其在生物分子检测等方面的应用，讨论了基于等离子耦合圆二色性和超手性近场在圆二色性增强方面的策略，介绍了基于横向手性光力的物质构型分选和基于结构光场光力效应的手性结构表征方法，并对该领域未来进一步的发展进行了展望。 AbstractChirality is a geometrical property where an object can not be superposed onto its mirror image via either a translational or a rotational operation. Since this type of symmetry is much harder to be maintained than to be broken, chirality exists widely in various macroscopic and microscopic structures. For example, proteins and nucleic acids are built of chiral amino acids and chiral sugar. In addition, DNA double helix, sugar, quartz, cholesteric liquid crystals and biomolecules are also chiral structures. Although molecules with different handedness have the same chemical construction, usually they would possess distinct chemical behaviors. Consequently, as an essential attribute of organism, the chiral representation of matter is of great significance in the fields of pharmacology, toxicology and pharmacodynamics. When electromagnetic wave interacts with chiral materials, special optical activity phenomena will appear, such as optical rotation, circular dichroism, and chiral optical force, which become a powerful tool for material chirality detection. Since the size of chiral molecule is much smaller than the wavelength of excitation light, the chiroptical effect of molecule itself is usually very weak, which greatly limits the accuracy of detection scheme. In recent years, the progress of nanophotonic technology is expected to enhance the weak chiral optical effect between light and matter at nanoscale, making it possible to detect chirality with high sensitivity and resolution. In this paper, the developments of chiral detection technology in recent years are reviewed, which focus on the micro/nano structure based enhanced circular dichroism and optical force effect. Besides, the corresponding applications are discussed. The mechanisms of chirality sensing for various nanophotonic platforms and outlined recent advances and future opportunities of major approaches for biosensing applications are reviewed. Firstly, the microscopic origin of surface-enhanced circular dichroism, as well as the theory of superchiral near-field generation in dielectric and plasmonic substrates are discussed. Secondly, the theory and mechanistic concept of plasmon-coupled circular dichroism in plasmonic nanoparticles, as well as the examples of hotspot-enhanced plasmon-coupled circular dichroism for biosensing applications are reviewed. Thirdly, the use of chiral and achiral plasmonic and dielectric nanoantennas, as well as plasmonic-dielectric hybrid systems for enhancing the optical chirality of biomolecules are reviewed. Fourthly, the theory of the optical force exerted on chiral nanoparticle is introduced. The optical sorting of chiral material with the use of the lateral optical force of complex optical field, the enhanced chiral optical force of plasmonic nanostructure, as well as the characterization of structured chirality using photoinduced force microscopy are reviewed. Finally, the future perspective of this rapidly developing field is presented at the end of this paper. PDF全文 芮光浩, 詹其文. 基于纳米光子学的手性检测与表征技术（特邀）[J]. 光子学报, 2022, 51(5): 0551301. Guanghao RUI, Qiwen ZHAN. Nanophotonic Methods for Chiral Sensing and Characterization（Invited）[J]. ACTA PHOTONICA SINICA, 2022, 51(5): 0551301.
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