戈惠明

基本简介

学习经历：

2012.9-2015.12 美国Scripps研究所（TSRI）化学系，博士后，导师：Prof. Ben Shen

2010.3-2012.7 南京大学化学化工学院，博士后，导师：姚祝军教授

2002.9-2007.6 南京大学生命科学学院，博士，导师：谭仁祥教授

1998.9-2002.6 南京大学生命科学学院，本科，导师：谭仁祥教授

工作经历：

2015.6-至今 南京大学教授

2009.1-2015.5 南京大学副教授

2007.7-2008.12 南京大学讲师

2015年 获国家自然科学基金优秀青年基金

2014年 南京大学博士生导师

2010年 教育部新世纪优秀人才

（1）天然产物的发现及生物功能研究：从特殊环境微生物中，通过传统的化学筛选和基因挖掘等方法，寻找和表征结构特殊、生物活性显著的分子，为新药创制提供先导化合物或源头分子。

（2）天然产物的生物合成研究：以微生物来源的结构新奇、活性显著的复杂天然产物为目标分子，从基因和蛋白水平揭示自然界神奇的生物化学过程，理解其中蕴涵的新型酶催化反应和生理拮抗机制。（3）天然产物的组合生物合成研究：在了解复杂天然产物生物合成的基础上，通过对其生物合成相关的基因和蛋白的改造达到提高产量，或改造并优化天然产物的结构

发表论文

2015    Wang, G.; Fan, J. Y.; Zhang, W. J.; Hua, C. P.; Chen, C. J.; Yan, W.; Ge, H. M.; Jiao, R. H.; Tan, R. X., Polyketides from Mantis-Associated Fungus Daldinia eschscholzii IFB-TL01. Chem Biodivers 2015, 12 (9), 1349-1355;    Song, Y. N.; Zhang, W. J.; Bi, S. F.; Jiao, R. H.; Tan, R. X.; Ge, H. M.*, New ansamycin analogues from the mutant strain of Streptomyces seoulensis. J Antibiot 2015, 68 (12), 757-759;    Song, Y. N.; Jiao, R. H.; Zhang, W. J.; Zhao, G. Y.; Dou, H.; Jiang, R.; Zhang, A. H.; Hou, Y. Y.; Bi, S. F.; Ge, H. M.*; Tan, R. X., New Ansamycin Derivatives Generated by Simultaneous Mutasynthesis. Org Lett 2015, 17 (3), 556-559;    Shi, X.; Wei, W.; Zhang, W. J.; Hua, C. P.; Chen, C. J.; Ge, H. M.; Tan, R. X.; Jiao, R. H., New tricycloalternarenes from fungus Alternaria sp. J Asian Nat Prod Res 2015, 17 (2), 143-148;    Shen, B.; Hindra; Yan, X. H.; Huang, T. T.; Ge, H. M.; Yang, D.; Teng, Q. H.; Rudolf, J. D.; Lohman, J. R., Enediynes: Exploration of microbial genomics to discover new anticancer drug leads. Bioorg Med Chem Lett 2015, 25 (1), 9-15;    Ren, R.; Chen, C. J.; Liu, X. X.; Ge, H. M.; Tan, R. X.; Jiao, R. H., Bioactive Trichothecenes Produced by the Myrothecium sp QB-1. Helv Chim Acta 2015, 98 (10), 1435-1441;    Ren, R.; Chen, C. J.; Hu, S. S.; Ge, H. M.; Zhu, W. Y.; Tan, R. X.; Jiao, R. H., Drimane Sesquiterpenoids from the Aspergillus oryzae QXPC-4. Chem Biodivers 2015, 12 (3), 371-379;    Pan, J.; Jin, J. L.; Ge, H. M.; Yin, K. L.; Chen, X.; Han, L. J.; Chen, Y.; Qian, L.; Li, X. X.; Xu, Y., Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPAR gamma-dependent manner. J Neuroinflamm 2015, 12; DOI 10.1186/s12974-015-0270-3.    Liu, T.; Ma, M.; Ge, H. M.; Yang, C. Y.; Cleveland, J.; Shen, B., Synthesis and evaluation of 8,4 ‘-dideshydroxy-leinamycin revealing new insights into the structure-activity relationship of the anticancer natural product leinamycin. Bioorg Med Chem Lett 2015, 25 (21), 4899-4902;    Ji, P.; Chen, C. M.; Hu, Y. A.; Zhan, Z. X.; Pan, W.; Li, R. R.; Li, E. G.; Ge, H. M*; Yang, G., Antiviral Activity of Paulownia tomentosa against Enterovirus 71 of Hand, Foot, and Mouth Disease. Biol Pharm Bull 2015, 38 (1), 1-6;    Hu, S. S.; Jiang, N.; Wang, X. L.; Chen, C. J.; Fan, J. Y.; Wurin, G.; Ge, H. M.; Tan, R. X.; Jiao, R. H., Prenylated diphenyl ethers from the mantis-associated fungus Aspergillus versicolor GH-2. Tetrahedron Lett 2015, 56 (25), 3894-3897;    Guo, Z. K.; Yan, W.; Tan, R. X.; Ge, H. M., Actinotetraose L, a new tetrasaccharide derivative isolated from the mycelia of Amycolatopsis sp HCa1. J Asian Nat Prod Res 2015, 17 (11), 1109-1113;    Chen, C. J.; Zhou, Y. Q.; Liu, X. X.; Zhang, W. J.; Hu, S. S.; Lin, L. P.; Huo, G. M.; Jiao, R. H.; Tan, R. X.; Ge, H. M.* Pseudallescheria, Antimicrobial and anti-inflammatory compounds from a marine fungus Pleosporales sp. Tetrahedron Lett 2015, 56 (45), 6183-6189;    Chen, C. J.; Liu, X. X.; Zhang, W. J.; Zang, L. Y.; Wang, G.; Ng, S. W.; Tan, R. X.; Ge, H. M.*, Sesquiterpenoids isolated from an endophyte fungus Diaporthe sp. Rsc Adv 2015, 5 (23), 17559-17565 2014    Chen, C. J., R. Jiang, G. Wang, R. H. Jiao, C. Tancharoen, K. Sudto, S. Vajarothai, S. Hannongbua, H. M. Ge*, and R. X. Tan.. Oligostilbenoids with Acetylcholinesterase Inhibitory Activity from Dipterocarpus alatus. Planta Medica 2014, 80, 1641-1646.    Guo, Z. K., R. Wang, W. Huang, X. N. Li, R. Jiang, R. X. Tan, and H. M. Ge*. Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3. Beilstein Journal of Organic Chemistry 2014, 10, 2677-2682.    Yan Wei,? Hui Ming Ge,? Gang Wang,? Nan Jiang,? Ya Ning Mei, Rong Jiang, Sui Jun Li, Chao Jun Chen, Rui Hua Jiao, Qiang Xu, Seik Weng Ng Ren Xiang Tan. Pictet–Spengler reaction based biosynthetic machinery in fungi. Proceedings of the National Academy of Sciences of the United States of America. 18138–18143. (? Co-First author)    Hui-Ming Ge, Tingting Huang, Jeffrey D. Rodolf, Jeremy R. Lohman, Sheng-Xiong Huang, Xun Guo, Ben Shen. Enediyne Polyketide Synthases Stereoselectively Reduce the beta-Ketoacyl Intermediates to beta-D-Hydroxyacyl Intermediates in Enediyne Core Biosynthesis. Organic Letters, 2014, 16, 3958-3961.    Wei Huang, Wen-Jing Zhang, Yi-Qing Cheng, Rong Jiang, Wei Wei, Chao-Jun Chen, Gang Wang, Rui-Hua Jiao, Ren-Xiang Tan*, Hui-Ming Ge*. Cytotoxic and Antimicrobial Flavonoids from Cryptocarya concinna. Planta Medica, 2014, 80, 925-930.    Wei Wei, Nan Jiang, Ya Ning Mei, Yan Liang Chu, Hui Ming Ge, Yong Chun Song, Seik Weng Ng, Ren Xiang Tan. Phytochemistry, 2014, 100, 103-109.    Yi-Qing Cheng, Rong Jiang, Wei Huang, Wei Wei, Chao-Jun Chen, Ren-Xiang Tan,* Hui-Ming Ge*. Hopeachinols E-K, novel oligostilbenoids from the stem bark of Hopea chinensis. RSC Advances, 2014, 4, 28901-28907.    Hao Chen Wu,? Hui Ming Ge,? Le Yun Zang, Yun Cheng Bei, Zhi Yuan Niu, Wei Wei, Xiu Jing Feng, Sen Ding, Seik Weng Ng, Ping Ping Shen, Ren Xiang Tan. Diaporine, a novel endophyte-derived regulator of macrophage differentiation. Organic & Biomolecular Chemistry, 2014, 12, 6545-6548. (? Co-First author)    Wu, Q.; Jiang, N.; Han, W. B.; Mei, Y. N.; Ge, H. M.; Guo, Z. K.; Weng, N. S.; Tan, R. X., Antibacterial epipolythiodioxopiperazine and unprecedented sesquiterpene from Pseudallescheria boydii, a beetle (coleoptera)-associated fungus. Org Biomol Chem 2014, 12 (46), 9405-9412; 2013    Ai Hua Zhang,  Xing Qi Wang, Wen Bo Han, Yang Sun, Ye Guo, Qi Wu, Hui Ming Ge, Yong Chun Song, Seik Weng Ng,  Qiang Xu, R. X. Tan,  Discovery of a New Class of Immunosuppressants from Trichothecium roseum Co-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif. Chemistry-an Asian Journal, 2013, 8, 3101-3107.    Wuringege, Zhi Kai Guo, Wei Wei, Rui Hua Jiao, Tong Yan, Le Yun Zang, Rong Jiang, Ren Xiang Tan, Hui Ming Ge*. Polyketides from the plant endophytic fungus Cladosporium sp IFB3lp-2. Journal of Asian Natural Producst Research 2013, 15, 928-933.    Haishi Qiao, Xiaoqing Chen, Lanfang Xu, Jingjing Wang, Guoyan Zhao, Yayi Hou, Hui Ming Ge, Ren-Xiang Tan, Erguang Li. Antitumor effects of naturally occurring oligomeric resveratrol derivatives. FASEB Journal, 2013, 27, 4561-4571.    Zhi Kai Guo, Rui Hua Jiao, Hai Fu Dai, WL Mei, RX Tan, HM Ge. Actinotetraoses I-K: Tetrasaccharide Metabolites Produced by an Insect-Derived Actinobacteria, Amycolatopsis sp HCa1. Chemistry & Biodiversity, 2013, 10, 296-302    Xiaolei Zhu, Lan Ye, Huiming Ge, Ling Chen, Nan Jiang, Lai Qian, Lingling Li, Rong Liu, Shen Ji, Su Zhang, Jiali Jin, Dening Guan, Wei Fang, Renxiang Tan*, Yun Xu* Hopeahainol A attenuates memory deficits by targeting ss-amyloid in APP/PS1 transgenic mice. Aging Cell, 2013, 12, 85-92.    Rui Feng; Ting Wang; Wei Wei; Ren-Xiang Tan; Hui Ming Ge*. Cytotoxic Constitutents from Cryptocarya maclurei. Phytochemistry, 2013, 90, 147-153.    Tong Yan, Zhi Kai Guo, Rong Jiang, Wei Wei, Ting Wang, Ye Guo, Yong Chun Song, Rui Hua Jiao, Ren Xiang Tan, Hui Ming Ge* New Flavonol and Diterpenoids from the Endophytic Fungus Aspergillus sp. YXf3. 2013, 79, 348-352.    Jingjing Wang, Xiaoqing Chen, Wei Wang W, Yating Zhang, You Jin, Hui Ming Ge, Erguang Li, Guang Yang. Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. Journal of Ethnopharmacology, 2013, 147, 114-121.    Shu Feng Bi, Zhi Kai Guo, Nan Jiang, Rui Hua Jiao, Hui Ming Ge, Ren Xiang Tan. New alkaloid from Streptomyces koyangensis residing in Odontotermes formosanus. Journal of Asian Natural Producst Research, 2013, 15, 422-425.    Rui Hua Jiao, Hao Xu, Jiang Tao Cui, Hui Ming Ge, Ren Xiang Tan. Neuraminidase Inhibitors from marine-derived actinomycete Streptomyces seoulensis. Journal of Applied Microbiology, 2013, 114, 1046-1053    Li-Li Feng, Xue-Feng Wu, Hai-Liang Liu, Wen-Jie Guo, Qiong Luo, Fei-Fei Tao, Hui-Ming Ge, Yan Shen, Ren-Xiang Tan, Qiang Xu, Yang Sun. Vaticaffinol, a resveratrol tetramer, exerts more preferable immunosuppressive activity than its precursor in vitro and in vivo through multiple aspects against activated T lymphocytes. Toxicology and Applied Pharmacology, 2013, 267, 167-173. 2012    Lan Lin, Hui Ming Ge, Tong Yan, Yan Hua Qin, Ren Xiang Tan* Thaxtomin A-deficient endophytic Streptomyces sp. enhances plant disease resistance to pathogenic Streptomyces scabies. Planta, 2012, 236, 1849–1861.    Zhi Kai Guo, Shou Bai Liu, Rui Hua Jiao, Ting Wang, Ren Xiang Tan*, Hui Ming Ge* Angucyclines from an insect-derived actinobacterium Amycolatopsis sp. HCa1 and their cytotoxic activity. Bioorganic & Medicinal Chemistry Letters 2012, 22, 7490-7493.    Le Yun Zang, Wei Wei,Ye Guo,Ting Wang,Rui Hua Jiao,Seik Weng Ng,Ren Xiang Tan,and Hui Ming Ge* Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Diaporthe sp. Journal of Natural Products, 2012, 75, 1744-1749.    Wei Fang, Shen Ji, Nan Jiang, Wei Wang, Guo Yan Zhao, Su Zhang, Hui Ming Ge, Qiang Xu, Ai Hua Zhang, Ying Lao Zhang, Yong Chun Song, Jie Zhang, Ren Xiang Tan. Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nature Communications, 2012, 3, 1039.    Hui Ming Ge, Lan-De Zhang, Ren Xiang Tan, and Zhu-Jun Yao. Protecting Group-free Total Synthesis of (-)-Lannotinidine B. Journal of the American Chemical Society, 2012, 134, 12323-12325. (IF=9.907)    Xiaoqing Chen, Haishi Qiao,Taixiang Liu, Ziying Yang, Lanfang Xu, Yunxia Xu, Hui Ming Ge, Ren Xiang Tan, Erguang Li. Inhibition of herpes simplex virus infection by oligomeric stilbenoids through ROS generation. Antiviral Research 2012, 95, 30-36.    Zhi Kai Guo, Gao Fei Zhang, Rui Hua Jiao, Yan Shen, Qiang Xu, Ren Xiang Tan, Hui Ming Ge*. Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp. HCa1. Planta Medica 2012, 78, 988-994.    Tong Yan, Ting Wang, Wei Wei, Nan Jiang, Yan Hua Qin, Ren Xiang Tan, Hui Ming Ge*. Polyphenolic Acetylcholinesterase Inhibitors from Hopea chinensis. Planta Medica 2012, 78, 1015-1019.    Hui Ming Ge, Han Sun, Nan Jiang, Yan Hua Qin, Huan Dou, Tong Yan, Ya Yi Hou, Christina Griesinger, and Ren Xiang Tan* Relative and absolute configuration of vatiparol (1 mg), a novel anti-inflammatory polyphenol. Chemistry – A European Journal, 2012, 18, 5213-5221.    Rui Feng, Zhi Kai Guo, Chun Min Yan, Erguang Li, Ren Xiang Tan, Hui Ming Ge*. Anti-inflammatory Flavonoids from Cryptocarya chingii. Phytochemistry 2011, 76, 98-105.    Zhi Kai Guo, Tong Yan, Ye Guo, Yong Chun Song, Rui Hua Jiao, Ren Xiang Tan, and Hui Ming Ge* p-Terphenyl and Diterpenoid Metabolites from Endophytic Aspergillus sp. YXf3. Journal of Natural Products, 2012, 75, 15-21.    Gao Fei Zhang, Wen Bo Han, Jiang Tao Cui, Zhi Kai Guo, Ren Xiang Tan, Hui Ming Ge*. Neuraminidase Inhibitory Polyketides from Marine-derived Fungus Phoma herbarum. Planta Medica 2012, 78, 76-78. (IF=2.153)    Le-Yun Zang, Wei Wei, Ting Wang, Ye Guo, Ren-Xiang Tan,* and Hui-Ming Ge* Isochromophilones from an endophytic fungus Diaporthe sp. Natural Products & Bioprospecting 2012, 2, 117-120. 2011    Zhi Kai Guo, Ting Wang, Ye Guo, Yong Chun Song, Ren Xiang Tan, Hui Ming Ge*. Cytotoxic Angucyclines from Amycolatopsis sp. HCa1, a Rare Actinobacteria Derived from Oxya chinensis. Planta Medica 2011, 77, 2057-2060.    Aijun Lin, Haibin Mao, Xi Zhu1, Huiming Ge, Renxiang Tan, Chengjian Zhu, Yixiang Cheng*. Organocatalytic Asymmetric CS Bond Formation: Synthesis of α-Methylene-β-mercapto Esters with Simple Alkyl Thiols. Advanced Synthesis & Catalysis, 2011, 353, 3301-3306.    Aijun Lin, Haibin Mao1, Xi Zhu, Huiming Ge, Renxiang Tan, Chengjian Zhu, Yixiang Cheng*. Organocatalytic Enantioselective Amination of Morita–Baylis–Hillman Carbonates with Masked Ammonia: A Facile Method for the Synthesis of Unprotected α-Methylene-β-Amino Esters. Chemistry - A European Journal, 2011, 17, 13676–13679.    Aijun Lin, Junying Wang, Hanbin Mao, Huiming Ge, Renxiang Tan, Chengjian Zhu, Yixiang. Cheng. Organocatalytic Asymmetric Michael-Type/Wittig Reaction of Phosphorus Ylides: Synthesis of Chiral alpha-Methylene-delta-Ketoesters. Organic Letters, 2011, 13, 4176-4179.    Yan Hua Qin, Jie Zhang, Jiang Tao Cui, Zhi Kai Guo, Nan Jiang, Ren Xiang Tan, Hui Ming Ge*. Oligostilbenes from Vatica mangachapoi with xanthine oxidase and acetylcholinesterase inhibitory activities. RSC Advances, 2011, 1, 135–141.    Gao Fei Zhang, Zhi Kai Guo, Wei Wang, Jiang Tao Cui, Ren Xiang Tan, Hui Ming Ge*. Neuraminidase inhibitory terpenes from endophytic Cochliobolus sp. Journal of Asian Natural Products Research 2011, 13, 761-764.    Hoong-Kun Fun, Kanokorn Sudto, Hui-Ming Ge, Ren-Xiang Tan, Supa Hannongbua, Suchada Chantrapromma. Hopeahainol C monohydrate. Acta Crystallographica Section E – Structure Reports Online 2011, 67, O1392-U527.    Hui Ming Ge, Wei Yan, Zhi Kai Guo, Qiong Luo, Rui Feng, Le Yun Zang, Yan Shen, Rui Hua Jiao, Qiang Xu, Ren Xiang Tan. Precursor-directed fungal generation of novel halogenated chaetoglobosins with more preferable immunosuppressive action. Chemical Communications 2011, 47, 2321–2323.    Ying Lao Zhang, Jie Zhang, Nan Jiang, Yan Hua Lu, Lu Wang, S. H. Xu, W. Wang, G. F. Zhang, Q. Xu, H. M. Ge, J. Ma, Y. C. Song, R X. Tan. Immunosuppressive Polyketides from Mantis-Associated Daldinia eschscholzii. J. Am. Chem. Soc. 2011, 133, 5931–5940.    Hui Ming Ge, Qiang Zhang, Shu Hai Xu, Zhi Kai Guo, Yong Chun Song,Wu Yang Huang, R. X. Tan. Chaetoglocins A–D, Four New Metabolites from the Endophytic Fungus Chaetomium globosum. Planta Medica, 2011; 77, 277–280.    Shu Feng Bi, Fang Li, Yong Chun Song, Ren Xiang Tan and Hui Ming Ge,* New Acrylamide and Oxazolidin Derivatives from a Termite-Associated Streptomyces sp. Natural Product Communications, 2011, 6, 353-355. 2010    Hui Ming Ge, Wen Hao Yang, Yan Shen, Nan Jiang, Zhi Kai Guo, Qiong Luo, Qiang Xu, Jing Ma, Ren Xiang Tan.  Immunosuppressive Resveratrol Aneuploids from Hopea chinensis. Chemistry – A European Journal, 2010, 16, 6338-6345.    Jie Zhang, Hui Ming Ge, Rui Hua Jiao, Jing Li, Hui Peng, Yu Rong Wang, Jun Hua Wu, Yong Chun Song, Ren Xiang Tan. Cytotoxic chaetoglobosins from the endophyte Chaetomium globosum. Planta Medica, 2010, 76, 1910-1914.    Hui Ming Ge, Hui Peng, Zhi Kai Guo, Jiang Tao Cui, Yong Chun Song, Ren Xiang Tan. Bioactive Alkaloids from the Plant Endophytic Fungus Aspergillus terreus. Planta Medica, 2010, 76, 822-824.    Qi Zhi Wang, Hui Ming Ge, Jie Zhang, Jun Hua Wu, Yong Chun Song, Yu Fei Zhang, Ren Xiang Tan. Cochliones A–D, four new tetrahydrochromanone derivatives from endophytic Cochliobolus sp. Journal of Asian Natural Products Research, 2010, 12, 485-491. 2009    Hui Ming Ge, Zhi Guo Yu, Jie Zhang, Jun Hua Wu, and Ren Xiang Tan. Bioactive Alkaloids from Endophytic Aspergillus fumigatus. Journal of Natural Products, 2009, 72, 753-755.    Hui Ming Ge, Wen Hao Yang, Jie Zhang, Ren Xiang Tan. Antioxidant oligostilbenoids from the stem wood of Hopea hainanensis. Journal of Agricultural and Food Chemistry, 2009, 57, 5756-5761.    Hui Ming Ge, Rui Hua Jiao, Yu Fei Zhang, Jie Zhang, Yu Rong Wang, Ren Xiang Tan. Cytotoxicity and phytotoxicity of trichothecene macrolides from Myrothecium gramminum. Planta Medica 2009, 75, 227-229.    Hui Ming Ge, Ren Xiang Tan Symbionts, an Important Source of New Bioactive Natural Products. Progress in Chemistry, 2009, 21, 30-46.    Da Hua Shi, Jun Hua Wu, Hui Ming Ge, Ren Xiang Tan. Protective effect of hopeahainol A, a novel acetylcholinesterase inhibitor, on hydrogen peroxide-induced injury in PC12 cells. Environmental Toxicology and Pharmacology, 2009, 28, 30-36.    Shu Xu, Hui Ming Ge, Yong Chun Song, Yao Shen, Hui Ding, Ren Xiang Tan. Cytotoxic Cytochalasin Metabolites of Endophytic Endothia gyrosa. Chemistry & Biodiversity 2009, 6, 739-745. 2008    Hui Ming Ge, Wei Yun Zhang, Gang Ding, Patchareenart Saparpakorn, Yong Chun Song, Supa Hannongbua, Ren Xiang Tan. Chaetoglobins A and B, Two Unusual Alkaloids from Endophytic Chaetomium globosum Culture. Chemical Communications, 2008, 5978-5980.    Hui Ming Ge, Chun Hua Zhu, Da Hua Shi, Li Dong Zhang, Dai Qian Xie, Jie Yang, Seik Weng Ng, Ren Xiang Tan. Hopeahainol A, an acetylcholinesterase inhibitor from Hopea hainanensis. Chemistry – A European Journal, 2008, 14, 376-381.    Hui Ming Ge, Yao Shen, Chun Hua Zhu, Shua Hua Tan, Ren Xiang Tan. Three Cytotoxic Alkaloids from Endophyte Fungi Penicillun sp. Phytochemistry, 2008, 69, 571-576.    Ying Lao Zhang, Hui Ming Ge, Wei Zhao, Hao Dong, Qiang Xu, Shu Hua Li, Jing Li, Jie Zhang, Yong Chun Song, Ren Xiang Tan. Unprecedented Immunosuppressive Polyketides from Daldinia eschscholzii, a Mantis-associated Fungus. Angewandte Chemie International Edition, 2008, 47, 5823-5826.    Xing Xi Gao, Hui Ming Ge, Wei Fa Zheng, Ren Xiang Tan NMR-based metabonomics for detection of Helicobacter pylori infection in gerbils: which Is more descriptive?  Helicobacter, 2008, 13, 103-111.    Ying Lao Zhang, Hui Ming Ge, Fang Li, Yong Chun Song, Ren Xiang Tan New phytotoxic metabolites from Pestalotiopsis sp. HC02, a fungus residing in Chondracris rosee Gut. Chemistry & Biodiversity, 2008, 5, 2402-2407. 2007    Wen Gu, Hui Ming Ge, Yong Chun Song, Hui Ding, Hai Liang Zhu, X. A. Zhao, Ren Xiang Tan. Cytotoxic Benzo[j]fluoranthene Metabolites of Hypoxylon truncatum IFB-18, an Endophyte on Artemisia annua. Journal of Natural Products, 2007, 70, 114-117.    Lei Shi, Hui Ming Ge, Shu Hua Tan, Huan Qiu Li, Ren Xiang Tan, Hai Liang Zhu. Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. European Journal of Medicinal Chemistry, 2007, 42, 558-564.    Li Na Zhang, Zhu Ping Xiao, Hui Ding, Hui Ming Ge, Chen Xu, Ren Xiang Tan, Hai Liang Zhu. Synthesis and cytotoxic evaluation of novel 7-O-modified Genistein derivatives. Chemistry & Biodiversity, 2007, 4, 248-255.    Xian Feng Huang, Ban Feng Ruan, Xiao Ting Wang, Chen Xu, Hui Ming Ge, Hai Liang Zhu, Ren Xiang Tan. Synthesis and cytotoxic evaluation of a series of resveratrol derivatives modified in C2 position. European Journal of Medicinal Chemistry, 2007, 42, 263-267.    Ping Cao, Xian Feng Huang, Hui Ding, Hui Ming Ge, Huan Qiu Li, Ban Feng Ruan, Hai Liang Zhu. Synthesis and Cytotoxic Evaluation of Substituted Urea Derivatives as nhibitors of Human-Leukemia K562 Cells. Chemistry & Biodiversity 2007, 4, 881-886. 2006    Hui Ming Ge, Chen Xu, Xiao Ting Wang, Bo Huang, Ren Xiang Tan. Hopeanol: a Potent Cytotoxin with a Novel Skeleton from Hopea exalata. European Journal of Organic Chemistry, 2006, 5551-5554.    Hui Ming Ge, Bo Huang, Shua Hua Tan, Da Hua Shi, Yong Chun Song, and Ren Xiang Tan. Bioactive Oligostilbenoids from the Stem Bark of Hopea exalata. Journal of Natural Products 2006, 69, 1800-1802.    Hui Ming Ge, Yong Chun Song, Jing Rong Chen, Shua Hu, Jian Yong Wu, and Ren Xiang Tan. Paranolin, a Metabolite with a Novel Xanthene-based Framework of Paraphaeosphaeria nolinaei. Helvetica Chimica Acta, 2006, 89, 502-506.    Rui Hua Jiao, Hui Ming Ge, Da Hua Shi, Ren Xiang Tan. An apigenin-derived xanthine oxidase inhibitor from Palhinhaea cernua. Journal of Natural Products, 2006, 69, 1089-1091.    Rui Hua Jiao, Shu Xu, Jun Yan Liu, Hui Ming Ge, Hui Ding, Chen Xu, Hai Liang Zhu, Ren Xiang Tan. Chaetominine, a cytotoxicalkaloid produced by endophytic Chaetomium sp. IFB-E015. Organic Letters, 2006, 8, 5709-5712.    Huan Qiu Li, Hui Ming Ge, Yun Xi Chen, Chen Xu, Lei Shi, Hui Ding, Hai Liang Zhu, Ren Xiang Tan. Synthesis and cytotoxic evaluation of a series of genistein derivatives Chemistry & Biodiversity, 2006, 3, 463-472.    Dang Gang , Yong Chun Song, Jing Rong Chen, Chen Xu, Hui Ming Ge, Xiao Ting Wang, Ren Xiang Tan. Chaetoglobosin U, a cytochalasan alkaloid from endophyfle Chaetomium globosum IFB-E019. Journal of Natural Products, 2006, 69, 302-304.    Ban Feng Ruan, Xian Feng Huang, Hui Ding, Chen Xu, Hui Ming Ge, Hai Liang Zhu, Ren Xiang Tan. Synthesis and cytotoxic evaluation of a series of resveratrol derivatives. Chemistry & Biodiversity, 2006, 3, 975-981. 2005    Hui Ming Ge, Yong Chun Song, Chen Ying Shan, Yong Hao Ye, and Ren Xiang Tan. New and cytotoxic anthraquinones from Pleospora sp. IFB-E006, an endophytic fungus in Imperata cylindrical. Planta Medica, 2005, 71, 1063-1065.    X. N. Wang, F. Wang, J. C. Du, H. M. Ge, R. X. Tan, J. K. Liu. A new marasmane sesquiterpene from the basidiomycete Russula foetens. Zeitschrift Fur Naturforschung Section B-A Journal of Chemical Sciences, 2005, 60, 1065-1067.

科研项目

1. 天然产物化学生物学，国家自然科学基金优秀青年基金

2. 一类抗幽门螺旋杆菌大环内酯化合物的生物合成研究，国家自然科学基金面上项目

3. Streptocolormycin的诱变-前体定向生物合成研究，国家自然科学基金面上项目

4. 海洋生物碱Fumigaclavine C的结构优化和初步成药性评价，国家海洋863项目

申请专利

1.戈惠明、陈玉胜、孔令东、丁晓琴. 一种白藜芦醇四聚体化合物及其制备方法和应用。申请人：南京大学，申请号：201110266508.

2，获得时间：2011年09月09日，发文序号：2011090900349860

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