PLC β2抗体 (B

PLC β2 Antibody (B-2) is an IgG2b κ mouse monoclonal PLC beta 2 antibody (also designated PLCB2 antibody, Phospholipase C Beta 2 antibody, 1-Phosphatidylinositol 45-Bisphosphate Phosphodiesterase Beta-2 antibody, or PLC-Beta-2 antibody) that detects the PLC beta 2 protein of mouse, rat and human origin by WB, IP, IF and ELISA. PLC β2 Antibody (B-2) is available as both the non-conjugated anti-PLC beta 2 antibody form, as well as multiple conjugated forms of anti-PLC beta 2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLCγ1, PLCγ2, PLC δ1, PLC δ2 and PLCe). PLC βs are the only PLC isforms that are regulated by G protein subunits and are activated by a heterotrimeric GTP-binding protein linked to various cell surface receptors. Two alternatively spliced forms (1181 and 1166 amino acids) of PLC β2 are generated in hematopoietic cells that differ in the carboxyl terminal sequence implicated in interaction of PLC β enzymes with Gαq.The pleckstrin homology domain of PLC β2 is required for its targeting to the membrane and for substrate hydrolysis and its linker region exerts an inhibitory efect on basal PLC β2 activity. PLC β2 plays a major role in platelet activation and is mainly expressed in the periphery of the islet and acinar cells in rat pancreas.

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