RNA聚合酶II的羧基末端结构域磷酸化激酶的综述

RNA聚合酶II（RNA Pol II）在真核生物的基因转录中起主要作用。真核生物中主要的调节方式之一是RNA Pol II羧基末端结构域（CTD）的磷酸化。当前的研究发现，CTD七肽重复序列中Ser2，Ser5，Ser7，Thr4和Tyr1的磷酸化在转录过程中起关键作用。因此，我们审查了磷酸化这些氨基酸残基的激酶的生物学功能和抑制剂，包括转录细胞周期蛋白依赖性蛋白激酶（CDK），含溴结构域的蛋白4（BRD4），Polo样激酶3（Plk3）和Abelson鼠白血病病毒致癌基因。 1和2（c-Abl1 / 2）。

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RNA polymerase II (RNA Pol II) plays a major role in gene transcription for eukaryote. One of the major modes of regulation in eukaryotes is the phosphorylation of the carboxyl-terminal domain (CTD) of RNA Pol II. The current study found that the phosphorylation of Ser2, Ser5, Ser7, Thr4 and Tyr1 among the heptapeptide repeats of CTD plays a key role in the transcription process. We therefore review the biological functions and inhibitors of kinases that phosphorylate these amino acid residues including transcriptional cyclin-dependent protein kinases (CDKs), bromodomain-containing protein 4 (BRD4), Polo-like kinases 3 (Plk3) and Abelson murine leukemia viral oncogene 1 and 2 (c-Abl1/2).