副研究员

2006.09-2011.06    吉林大学(硕博连读)-生物化学与分子生物学专业，理学博士学位

2011.06-2020.11    中科院新疆理化技术研究所-植物资源化学重点实验室，助理研究员

2018.05-2019.05    中国科学院上海药物所，中科院药物创新研究院，访问学者

2020.11-至今      中科院新疆理化技术研究所-植物资源化学重点实验室，副研究员

主要研究领域及成就：  

    基于新疆特色药用植物资源，围绕糖尿病和肿瘤等重大疾病，开展中药及民族药的活性成分或化合物筛选、药效学评价及作用机制的研究工作，深入挖掘具有良好成药性的候选或先导化合物，为地区民族药创新药物研发提供科学的理论依据。

    承担自治区和中科院等省部级科研项目10个，主持4项，累积科研经费300万，发表了学术论著10篇，SCI收录8篇，第一作者4篇(平均IF>5)。

代表性文章：  

(1) Dan Tang; Liu Liu; Dildar Ajiakber; Jianping Ye; Jianjun Xu;  Xuelei Xin*; Haji Akber Aisa*; Anti-diabetic effect of？Punica granatum flower polyphenols extract in type 2？diabetic？rats: activation of Akt/GSK-3β and inhibition of IRE1α-XBP1 pathways, Frontiers in Endocrinology, 2018, 9: 586-596.

(2) Dan Tang; Qibin Chen; Xuelei Xin; Haji Akber Aisa*; Anti-diabetic Effect of Three New Norditerpenoid Alkaloids in vitro and Potential Mechanism via PI3K/Akt Signaling Pathway, Biomedicine & Pharmacotherapy. 2017, 87: 145-152.

(3) Dan Tang; Lianzhen Xie; Xulei Xin; Haji Akber Aisa*; Journal of Pharmacognosy and Phytochemistry, 2016, 4(2): 7-13.

(4) Dan Tang; Dongli Liao; Qiankun Zhu; Fangyuan Wang and et al. Fluorescence turn-on detection of a protein through the displaced single-stranded DNA binding protein binding to a molecular beacon. Chem. Commun., 2011, 47, 5485–5487.

(5) Aobulikasimu Hasan; Dan Tang; Dilaram Nijat; Hequn Yang; H. A. Aisa*; Diterpenoids from Euphorbia glomerulans with potential reversal activities against P-glycoprotein-mediated multidrug resistance, Bioorganic Chemistry 2021,117, 105442. 

(6) HequnYang#; AytillaMamatjan#; Dan Tang; Haji Akber Aisa*; Jatrophane diterpenoids as multidrug resistance modulators from Euphorbia sororia. Bioorganic Chemistry, 2021, 112: 1-13. 

(7) Liu Liu#; Mrs Mireguli Yasen#; Dan Tang; Xuelei Xin*; Haji Akber Aisa*; Polyphenol-enriched extract of Rosa rugosa Thunb regulates lipid metabolism in diabetic rats by activation of AMPK pathway. Biomedicine & Pharmacotherapy, 2018, 100: 29-35.

(8) Liu Liu; Dan Tang; Haiqing Zhao; Xulei Xin*; Haji Akber Aisa*; Hypoglycemic effect of the polyphenols rich extract from Rose rugosa Thunb on high fat diet and STZ induced diabetic rats. Journal of Ethnopharmacology, 2017, 200: 174-181.

(9) Ayitila Maimaitijiang#; Bianlin Wang#; Hequn Yang; Dan Tang; Yongqiang Liu; Haji Akber Aisa*; Discovery of a novel highly potent and low-toxic jatrophane derivative enhancing the P-glycoprotein-mediated doxorubicin sensitivity of MCF-7/ADR cells. European Journal of Medicinal Chemistry, 2022, 244: 114822. 

(10) Haji-Akber Aisa, Xuelei Xin , Dan Tang. Chemical constituents and their pharmacological activities of plants from Cichorium genus[J]. Chinese Herbal Medicines, 2020.12( 3):224-236.  

代表性专利：  

1.阿吉艾克拜尔·艾萨, 杨贺群, 汤丹, 一种对叶大戟果实中假白榄烷型二萜化合物及制备方法和用途, CN112661644A（已授权）

2.阿吉艾克拜尔·艾萨，奥布力喀斯木·艾散，汤丹，从密花大戟中分离的大环二萜类化合物及其制备方法和用途，CN111592462A（已授权）

3.阿吉艾克拜尔·艾萨,杨贺群,王边琳,汤丹,阿依提拉·麦麦提江, 一种假白榄烷型二萜衍生物及其制备方法和用途, CN113402483A（已授权）

研究领域：

中药及民族药的有效成分或化合物生物活性筛选、药效学评价及作用机制的研究