刘丽赏

个人简介：

刘丽赏，教授，女，1985年4月生，2014年毕业于韩国庆熙大学，获博士学位，博士生、硕士生导师。研究方向为生化分析。沂蒙学者第四层次人才，中国国际“互联网+”大赛评审专家，山东省大学生创新创业训练计划项目评审专家，山东省科技专家库专家。

承担的主要科研项目:

基于CaCO3晶体原位生长的QCM检测新方法的研究，国家自然科学基金面上项目(21675076)，起止日期：2017/01-2020/12，经费金额：65万元,负责人：刘丽赏

生物条形码金磁纳米双信号放大检测肿瘤Endoglin 传感器研究，项目类别：国家自然科学基金青年基金项目（81502585），起止日期：2016/01-2018/12，经费金额：18万元，负责人：刘丽赏

生物条形码金磁颗粒检测肿瘤Endoglin生物芯片的研究，项目类别：中国博士后科学基金面上项目，项目编号：2015M572419，起止日期：2015/09-2016/12，经费金额：5万元，负责人：刘丽赏

基于石英晶体微天平技术的生物传感器研究，项目类别：临沂大学高层次人才启动基金，立项单位：临沂大学，项目编号：LYDX2016BS011，起止日期：2016/09-2018/08，经费金额：20万元，负责人：刘丽赏

研究生教育优质课程建设，项目类别：临沂大学研究生教育质量提升工程项目（YZKC2002），起止日期：2021/01-2022/12，经费金额：3万元，负责人：刘丽赏

代表性学术成果:

Lishang Liu, Jong-Min Kim, Woo-Sik Kim. In situ discrimination of polymorphs and phase transformation of sulfamerazine using QCM. Analytica Chimica Acta. 2022, 1221:340137.

Jinrong Chen, Shihao Zhang, Yuhan Wang, Ruwen Xie, Lishang Liu*, Yan Deng. In Vivo Self-Assembly Based Cancer Therapy Strategy. Journal of Biomedical Nanotechnology. 2020,16:997-1017.

刘丽赏，姜耀，李雪梅，张书圣. 基于石英晶体微天平的信号放大技术在肿瘤标志物检测中的应用. 中国科学：化学. 2019, 49(2): 276-284.

Lishang Liu, Congcong Wu, Shusheng Zhang*. Ultrasensitive Detection of DNA and Ramos Cell Using In Situ Selective Crystallization Based Quartz Crystal Microbalance. Analytical Chemistry. 2017, 89: 4309-4313.

Congcong Wu, Zhaomei Sun, Lishang Liu*. Quantitative control of CaCO3 growth on quartz crystal microbalance sensors as a signal amplification method. Analyst. 2017,142, 2547-2551.

Lishang Liu, Jong-Min Kim, Woo-Sik Kim*. Quartz Crystal Microbalance Technique for in-situ Analysis of Supersaturation in Cooling Crystallization. Analytical Chemistry. 2016, 88: 5718-5724.

Lishang Liu, Jong Min Kim, Woo-Sik Kim*. Simple and Reliable Quartz Crystal Microbalance Technique for Determination of Solubility by Cooling and Heating Solution. Analytical Chemistry. 2015, 87: 3329-3335.

Lishang Liu, Jong Min Kim, Sang-Mok Chang, Guang Jin Choi, and Woo-Sik Kim*. Quartz Crystal Microbalance Technique for Analysis of Cooling Crystallization. Analytical Chemistry. 2013, 85, 4790–4796.

Lishang Liu, XiaoLing Lu*, Yong-Xiang Zhao*. Aptamer-based Strategies for Cancer Diagnosis and Therapy. Journal of Nanoscience & Nanotechnology. 2016,16:6611-6621.

Lishang Liu, Hongna Liu, Li Song, Yan Deng, Xiaolong Li, Nongyue He*. Fabrication and Characterization of Streptavidin γ-Fe2O3@Au Nanocomposites for Biological Application. Acta Chimica Sinica. 2010, 68: 2041-2046.

Lishang Liu, Nucleic Acid Amplification Strategies for Biosensing, Bioimaging and Biomedicine Chapter 10: Nucleic Acid Amplification Strategies Based on QCM 2019. 04: 197-209, Springer.

张怀荣，刘丽赏，黄训，滕万清，胡善文，李学明，功能化纳米材料在生化分析中的应用 第二章 芯片表面传感技术及其在生化分析中的应用，科学出版社，2021, 06: 94-162.

Hongna Liu, Song Li, Lishang Liu, Nongyue He. Multiplex single nucleotide polymorphisms genotyping using solid-phase single base extension on magnetic nanoparticles. Analytical biochemistry. 2009, 386:126-128.

Hongna Liu, Song Li, Lishang Liu, Lan Tian, Nongyue He. An integrated and sensitive detection platform for biosensing application based on Fe@Au magnetic nanoparticles as bead array carries. Biosensors and Bioelectronics. 2010, 26:1442-1448.

Song Li, Hongna Liu, Lishang Liu, Lan Tian, Nongyue He. A novel automated assay with dual-color hybridization for single-nucleotide polymorphisms genotyping on gold magnetic nanoparticle array. Analytical Biochemistry. 2010, 405:141-143.

Hongna Liu, Li Song, Lishang Liu, Lan Tian, Yingying Jia, Zhiyang Li, Yan Deng, Nongyue He. Single Nucleotide Polymorphism Genotyping Based on Magnetic Bead Array and Dual-color Hybridization. Chinese Journal of Analytical Chemistry. 2010, 38:1708-1713.

Hongna Liu, Song Li, Lan Tian, Lishang Liu, Nongyue He. A novel single nucleotide polymorphisms detection sensors based on magnetic nanoparticles array and dual-color single base extension. Journal of Nanoscience & Nanotechnology. 2010, 10: 5311-5315.

Hongna Liu, Song Li, Lishang Liu, Lan Tian, Yan Deng, Zhiyang Li, Yabin Dai, Nongyue He. Magnetic Particle-based Single Nucleotide Polymorphism, Detection Method Using Linker-Polymerase Chain Reaction. Acta Chimica Sinica. 2009, Vol. 67:1797-1802.

专利：

一种核酸可视化检测的生物探针及试剂盒和非诊断目的的可视化检测核酸的方法，申请号：202210360855.X，临沂大学，刘丽赏，陈晋荣，谢儒雯，朱科晓，李娜，张书圣

一种基于晶体生长的QCM信号放大方法，申请号：201910683624.0, 临沂大学, 刘丽赏，吴从从，陈晋荣，程奕涵，张书圣

一种基于QCM的核酸序列检测方法，申请号：201910683979.X, 临沂大学,刘丽赏，吴从从，陈晋荣，张振麟，张书圣

一种基于QCM的细胞检测方法，申请号：201910683907.5, 临沂大学,刘丽赏，吴从从，陈晋荣，程奕涵，朱家政，张书圣

获奖情况：

2022年3月，山东省教学成果二等奖,地方高校化学学科硕士研究生科学素养培育体系的改革与实践,时鹏飞，刘丽赏，张怀荣，曲宗金，付厚利，宋昕玥，孙英男，王丹丹，李雪梅，张书圣

2019年12月，山东省高等学校科学技术奖二等奖,核酸载体的构建及其在传感诊疗上的应用研究,郭英姝，张怀荣，刘丽赏，李琼，张书圣

电子邮箱：[email protected]电话：15588178330