MCP

MCP-1（单核细胞趋化蛋白-1），也称为趋化因子（CC-基序）配体 2 (CCL2)，来自 CC 趋化因子家族。它在炎症过程中起着至关重要的作用，它会吸引或增强其他炎症因子/细胞的表达。它通过炎症细胞如单核细胞/巨噬细胞和其他细胞因子在炎症部位的迁移和浸润这一主要机制导致许多疾病的进展。MCP-1 已直接或间接参与多种疾病的发病机制，如新型冠状病毒、癌症、神经炎症性疾病、类风湿性关节炎、心血管疾病。已在 COVID-19 患者中观察到 MCP-1 水平升高，并被证明是与 IP-10 和疾病肢体相关的生物标志物。

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MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif) ligand 2 (CCL2), is from family of CC chemokines. It has a vital role in the process of inflammation, where it attracts or enhances the expression of other inflammatory factors/cells. It leads to the advancement of many disorders by this main mechanism of migration and infiltration of inflammatory cells like monocytes/macrophages and other cytokines at the site of inflammation. MCP-1 has been inculpated in the pathogenesis of numerous disease conditions either directly or indirectly like novel corona virus, cancers, neuroinflammatory diseases, rheumatoid arthritis, cardiovascular diseases. The elevated MCP-1 level has been observed in COVID-19 patients and proven to be a biomarker associated with the extremity of disease along with IP-10. This review will focus on involvement and role of MCP-1 in various pathological conditions