MYD88 先天性免疫信号转导接头（MYD88）基因

该基因编码一种胞质衔接蛋白，该蛋白在先天性和适应性免疫反应中起着核心作用。这种蛋白质在白细胞介素 1 和 Toll 样受体信号通路中起着重要的信号转导作用。这些途径调节许多促炎基因的激活。编码的蛋白质由一个 N 端死亡结构域和一个 C 端 Toll-interleukin1 受体结构域组成。该基因缺陷的患者对化脓性细菌感染的易感性增加。交替剪接导致多个转录本变体。[RefSeq 提供，2010 年 2 月]

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like Receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic Bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]