谷氨酸

谷氨酸-半胱氨酸连接酶，又称γ-谷氨酰半胱氨酸合成酶，是谷胱甘肽合成的第一限速酶。该酶由两个亚基组成，一个重催化亚基和一个轻调节亚基。该基因座编码催化亚基，而调节亚基来自位于染色体 1p22-p21 上的不同基因。由于γ-谷氨酰半胱氨酸合成酶缺乏和心肌梗塞易感性，该位点的突变与溶血性贫血有关。[RefSeq 提供，2010 年 10 月]

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting Enzyme of glutathione synthesis. The Enzyme consists of two subunits, a heavy catalytic subunit and a LIGHT regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]