促肾上腺皮质激素释放激素受体 2（CRHR2）基因

该基因编码的蛋白属于 G 蛋白偶联受体 2 家族，促肾上腺皮质激素释放激素受体亚家族。该受体对促肾上腺皮质激素释放激素 (CRH) 具有高亲和力，并且还结合 CRH 相关肽，例如尿皮质素。 CRH 在下丘脑中合成，在协调对压力和免疫挑战的内分泌、自主神经和行为反应方面起着重要作用。对小鼠的研究表明，这种受体可能参与调节心血管稳态。已针对该基因描述了编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 1 月]

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related Peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]