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世界著名化学家
Erick M. Carreira
2019/4/10 世界著名化学家 Comment: 0 Author: Peng Li3,616views ■
![]() Erick M. Carreira教授1963年生于哈瓦那、古巴(Havana Cuba)。现为苏黎世联邦理工学院有机化学教授,ACS旗下杂志Organic Letter主编, (图片来自:Org Lett), 自2021年起担任J. Am. Chem. Soc.主编。 经历 1984年 University of Illinois at Urbana-Champaign, B.S. Scott E. Denmark; 1990年 Harvard University, Ph.D. David A. Evans; 1992年 California Institute of Technology, Postdoctoral,Peter Dervan; 1996年California Institute of Technology,助理教授 1997年California Institute of Technology, 教授 1998年-现在Swiss Federal Institute of Technology Zurich, 教授 获奖经历 American Chemical Society Award in Pure Chemistry; Nobel Laureate Signature Award; Fresenius Award; David and Lucile Packard Foundation Fellowship in Science; Alfred P. Sloan Fellowship; Camille and Henry Dreyfus Teacher Scholar Award; Merck Young Investigator Award; Eli Lilly Young Investigator Award; Pfizer Research Award, National Science Foundation CAREER Award; Arnold and Mabel Beckman Young Investigator Award; Camille and Henry Dreyfus New Faculty Award; the Associated Students of the California Institute of Technology Annual Award in Teaching; Richard M. Badger Award in Teaching; 研究概览 1.生物活性分子的全合成 Erick M. Carreira教授一直致力于有生物活性和结构复杂的天然产物分子高效全合成,课题组至今已合成许多天然产物,图一为代表性分子的合成。其中,Chlorosulpholipid Cytotoxin的合成工作发表于顶级期刊Nature【1】。 图1:Representative Synthesis
2.合成策略的开发 Erick M. Carreira教授的合成方法学主要包括一下方面:联烯不对称烷基化反应{2}(图2a),不对称的烯丙基取代反应及其机理研究[3,4](图2b, c),对映选择性和非对映选择性的双催化剂在手性合成中的应用[5](图2d),非活化双键的氢氯化反应[6](图2e),环丙烷和环丙烯的不对称三氟甲基化反应[7](图2f),水相中的不对称转移氢化反应[8](图2g)。 a: Iridium-Catalyzed Enantioconvergent Allenylic Alkylation b: Iridium-Catalyzed Enantioconvergent Allylic Substitution c: Mechanistic Studies Regarding the Iridium Catalyzed Enantioselective Allylic Substitution d: Enantio- and Diastereodivergent Dual Catalysis and Its Application e: Trifluoromethylation of Cyclopropanes & Cyclopropenes f: Hydrochlorination of Unactivated Olefins g: Asymmetric Transfer Hydrogenations in Water 图2:Representative Catalytic Methods 药物化学Erick. M. Carreira教授在药物活性片段及活性方面也有许多研究,活性分子的氟化,杂环SF5化反应(图3a),螺环胺(图3b),氧杂环丁烷(图3c)。 a: 杂环SF5化反应 b:螺环胺合成 c:氧杂环丁烷合成 图3:Representative Workin Medicinal Chemistry 参考文献 1.C. Nilewski, R.W. Geisser, E. M. Carreira, Nature 2009, 547, 573.doi.org/10.1038/nature07734. D.A. Petrone, M. Isomura, I. Franzoni, S.L. Rössler, E.M. Carreira, J. Am. Chem. Soc. 2018, 140,4697. DOI: 10.1021/jacs.8b01416. J. Y. Hamilton, D. Sarlah, E. M. Carreira, J. Am. Chem. Soc. 2014, 136, 3006. DOI: 10.1021/ja412962w. S.L. Rössler, S.Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 3603-3606.DOI: 10.1021/jacs.6b12421. a: S. Krautwald, D. Sarlah, M. A. Schafroth, E. M. Carreira, Science, 2013, 340, 1065.DOI: 10.1126/science.1237068; b: (Perspective) S. Krautwald, E.M. Carreira, J. Am. Chem. Soc. 2017, 139, 5627-5639. DOI: 10.1021/jacs.6b13340. a: B. Morandi, E. M. Carreira, Angew. Chem. Int. Ed. 2010, 49, 938. doi.org/10.1002/anie.200905573;b: B. Morandi, E. M. Carreira, Angew. Chem. Int. Ed. 2010, 49, 4294.doi.org/10.1002/anie.201000787; B. Gaspar, E. M. Carreira, Angew. Chem. Int. Ed. 2008, 47, 5758. doi.org/10.1002/anie.200801760. O. Soltani, M. A. Ariger, H. Vázquez-Villa, E. M. Carreira, Org. Lett. 2010, 12, 2893. DOI: 10.1021/ol1008894.链接 Erick M. Carreira Group. Org. Lett. Editor Profile.
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