The Use of Cinchona Alkaloid Derivatives as Chiral Ligands and Organocatalysts in Asymmetric Catalysis
:Cinchona alkaloids are natural products extracted from cinchona plants, which contain quinine,quinidine, cinchonine, and cinchonidine. During the past 30 years, due to their attractive structuralproperties, these compounds have been used as chiral skeletons and organocatalysts in asymmetric organicsynthesis. In this review, we summarize the applications of cinchona alkaloids derivatives inasymmetric catalysis recently developed by our group, including oxidation, reduction, and C-C bondsformation. These studies have solved some of the problems with the various asymmetric reactions discussed,while also enriching alkaloids chemistry, providing new ideas for the design and synthesis ofchiral catalysts, and providing abundant experimental data for the chiral induction process.
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