“百人计划”特聘研究员、博士生导师

学习经历

1. 2009-2014 浙江大学医学院生物化学与分子生物学专业 博士

2. 2007-2009 武汉大学医学院生物化学与分子生物学专业 硕士

3.2003-2007 武汉工程大学化工与制药学院生物工程专业 学士

工作经历

1. 2018 -至今 重庆大学医学院 研究员

2.2014-2018 浙江大学生命科学研究院 博士后

研究方向、教学课程

1、 多组学特别是单细胞组学技术解析本能行为的分子细胞基础；

2、 脑-体器官的相互作用及其对神经代谢调控的影响。

成果：1.文章2.专利3.项目4.获奖

近期发表研究论文（#第一作者，*通讯作者）

1.Huang R#,*, Song T#, Su H#, Lai Z, Qin W, Tian Y, Dong X, Wang L* . High-fat diet enhances starvation-induced hyperactivity via sensitizing hunger-sensing neurons in Drosophila.Elife.2020;9:e53103.

2.Song T, Su H, Yin W, Wang L, Huang R*. Acetylation modulates LC3 stability and cargo recognition. FEBS Lett. 2019 Feb;593(4):414-422. （Highlighted paper）

3.Yang Z#,Huang R#, Fu X#, Wang G, Qi W, Mao D, Shi Z, Shen WL, Wang L. A post-ingestive amino acid sensor promotes food consumption in Drosophila.Cell Res. 2018 Oct;28(10):1013-1025.

4.Yu Y#,Huang R#,*, Ye J, Zhang V, Wu C, Cheng G, Jia J, Wang L*. Regulation of starvation-induced hyperactivity by insulin and glucagon signaling in adult Drosophila.Elife. 2016 Sep 9;5. /eLife.15693.

5.Huang R, Xu Y, Wan W, Shou X, Qian J, You Z, Liu B, Chang C, Zhou T, Lippincott-Schwartz J, Liu W. Deacetylation of nuclear LC3 drives autophagy initiation under starvation.Mol Cell, 2015. 57(3): p. 456-466. (Previewed by Mol Cell and Autophagy; Recommended by Faculty of 1000.)

6.Huang R, Liu W. Identifying an essential role of nuclear LC3 for autophagy.Autophagy. 2015 May 4;11(5):852-3.

7.He C#,Huang R#, Du F, Zheng F, Wei L, Wu J. LDL oxidation by THP-1 monocytes: implication of HNP-1, SgIII and DMT-1. Clin Chim Acta. 2009. 402(1-2):102-6.

8.Xu Y, Wan W, Shou X,Huang R, You Z, Shou Y, Wang L, Zhou T, Liu W. TP53INP2/DOR, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of the POLR1/RNA polymerase I preinitiation complex at rDNA promoters.Autophagy.2016 Jul 2;12(7):1118-28.

9.Song TT, Bi YH, Gao YQ,Huang R, Hao K, Xu G, Tang JW, Ma ZQ, Kong FP, Coote JH, Chen XQ, Du JZ. Systemic pro-inflammatory response facilitates the development of cerebral edema during short hypoxia.J Neuroinflammation. 2016 Mar 11;13(1):63.

10. Chang C, Su H, Zhang D, Wang Y, Shen Q, Liu B,Huang R, Zhou T, Peng C, Wong CC, Shen HM, Lippincott-Schwartz J, Liu W. AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation.Mol Cell.2015 Dec 17;60(6):930-40.

11. Liu B, Fang M, Hu Y, Huang B, Li N, Chang C,Huang R, Xu X, Yang Z, Chen Z, Liu W. Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation.Autophagy. 2013.10(3).

12. Guo Y, Chang C,Huang R, Liu B, Bao L, Liu W. AP1 is essential for generation of autophagosomes from the trans-Golgi network. J Cell Sci. 2012. 1;125(Pt 7):1706-15.