作为中性脂质储存细胞器，脂滴在细胞代谢和生长中起着重要作用。在这项研究中，我们基于萘酰亚胺衍生物开发了三种靶向具有DA型结构的脂滴的荧光探针，分别命名为TPA-NDI-1、TPA-NDI-2和TPA-NDI-3。有趣的是，这三种化合物表现出极性敏感特性，在甲苯中发出绿黄色荧光，在二氯甲烷中发出红色荧光。同时，它们在DMSO/H 2混合溶液中均具有AIE效应O，适合细胞内脂滴成像。此外，这三种探针表现出优异的pH和动力学稳定性、低生物毒性和大斯托克斯位移。所有这些特性表明这三种化合物可以用作脂滴可视化检测的潜在探针。

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As a neutral lipid storage organelle, lipid droplets play fundamental roles in cell metabolism and growth. In this study, we developed three fluorescent probe targeting lipid droplets with D-A type structures based on naphthalimido derivatives, which were named as TPA-NDI-1, TPA-NDI-2 and TPA-NDI-3. Interestingly, the three compounds exhibited polarity-sensitive properties which emitted greenyellow fluorescence in toluene and red fluorescence in dichloromethane. Meanwhile, they all possessed AIE effect in mixed solution of DMSO/H2O, which were suitable to intracellular lipid droplets imaging. Moreover, the three probes exhibited excellent pH and kinetic stability, low biotoxicity and large Stokes shift. All these properties suggest that the three compounds can be used as potential probes for lipid droplets visualized detection.