基于明胶的水凝胶系统是一种刺激响应性、生物相容性和可生物降解的聚合物系统，具有类似固体的流变性，将水分缠绕在其多孔网络中，逐渐突出以组装分层交联排列。胶原蛋白的水解引导明胶构建，保留精氨酰甘氨酰天冬氨酸和基质金属蛋白酶敏感的变性位点，进一步限制对凝胶内缠结的化学物质的接触（例如细胞封装），调节封装有效负载的释放并向凝胶提供机械信号。相邻的单元格。由于其较高的孔隙率和机械性能，利用各种类型的功能可调节生物聚合物作为水凝胶中的支架材料已变得极具吸引力；因此，可以进一步调节蛋白质、肽、治疗分子等的更高负载。此外，结冷胶浓度受损的刺激介导的明胶基水凝胶在生物医学和组织工程应用中表现出良好的剪切稀化和自我恢复特性。因此，这篇当代评论提出了明胶基水凝胶的简明版本，作为各种生物医学应用的可能的生物材料。此外，本文还概述了明胶的多种来源及其结构特征，涉及刺激水凝胶发育和治疗分子（例如蛋白质、肽、基因、药物等）的递送方法、现有挑战和克服设计，特别是来自药物输送的观点。

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A gelatin-based hydrogel system is a stimulus-responsive, biocompatible, and biodegradable polymeric system with solid-like rheology that entangles moisture in its porous network that gradually protrudes to assemble a hierarchical crosslinked arrangement. The hydrolysis of collagen directs gelatin construction, which retains arginyl glycyl aspartic acid and matrix metalloproteinase-sensitive degeneration sites, further confining access to chemicals entangled within the gel (e.g., cell encapsulation), modulating the release of encapsulated payloads and providing mechanical signals to the adjoining cells. The utilization of various types of functional tunable biopolymers as scaffold materials in hydrogels has become highly attractive due to their higher porosity and mechanical ability; thus, higher loading of proteins, peptides, therapeutic molecules, etc., can be further modulated. Furthermore, a stimulus-mediated gelatin-based hydrogel with an impaired concentration of gellan demonstrated great shear thinning and self-recovering characteristics in biomedical and tissue engineering applications. Therefore, this contemporary review presents a concise version of the gelatin-based hydrogel as a conceivable biomaterial for various biomedical applications. In addition, the article has recapped the multiple sources of gelatin and their structural characteristics concerning stimulating hydrogel development and delivery approaches of therapeutic molecules (e.g., proteins, peptides, genes, drugs, etc.), existing challenges, and overcoming designs, particularly from drug delivery perspectives.