一  基本情况     

  叶磊，副教授，入选山东大学青年学者未来计划。 天津大学姚芳莲教授和李俊杰教授（国家优青团队）博士，美国华盛顿大学Buddy Rather(美国工程院院士) 课题组博后。近年来，一直从事新型抗蛋白粘附材料研发及其用于医用传感，可注射水凝胶局部给药和抗污涂层制备等方面的研究。以第一作者或通讯作者在 ACS Nano（IF:17.1）, Journal of Materials Chemistry A（IF:14.5）, Materials Today Nano（IF:13.3）, Journal of Nanobiotechnology（IF:10. 4）, Acta Biomaterialia（IF:9.5） 等国际一流学术期刊发表论文 20 余篇，参编英文论著 1 部， 以第一发明人申请中国发明专利 2 项， PCT 专利 1 项。作为项目负责人承担国家自然科学、山东省自然科学基金和企业横向等项目 6 项，参与美国 JDRF 项目 1 项。现任Brain-X和 Pharmaceutical Sciences advances期刊青年编委，Micromachines(IF:3.5)杂志客座编辑。中国化学学会会员、美国化学会会员，中国生物材料学会会员，中国药学会会员，中国生物医学工程学会会员等学术兼职。

通讯地址：山东省济南市历下区文化西路44号山东大学趵突泉校区

E-mail: [email protected]; [email protected]

个人主页： https://faculty.sdu.edu.cn/yelei/en/index.htm  (English)

二 主要学习和工作经历概述

2023.9至今 山东大学，药学院，副教授

2019-2023 山东大学，药学院，副研究员

2016-2018 美国华盛顿大学，博士后；

       （美国工程院院士Prof. Buddy D. Ratner课题组，从事等离子体设备研究，同时基于等离子体技术和两性离子聚合物进行表面抗蛋白涂层制备及其用于药物递送的研究）

2012-2016 天津大学，生物化工（医用高分子），博士

      （姚芳莲教授和李俊杰教授（国家优青）团队，从事新型抗蛋白粘附材料的开发及其用于纳米载体和凝胶局部给药的研究）

三 研究领域

1.可注射凝胶/喷雾用于抗植入材料组织粘连的研究；

2.可注射水凝胶用于局部药物递送的研究；

3.医用凝胶用于柔性传感与健康监测的研究  

四 教学工作

本科生课程《药剂学》、《医用水凝胶材料概述》

研究生课程《现代药物制剂技术》

指导一名硕士研究生获得2022年度国家奖学金

五 代表性科研成果（第一作者/通讯作者）

参编专著

1.     Lei Ye, Fanglian Yao and Junjie Li. Chapter 6 Peptide and protein-based hydrogel; Sustainable Hydrogels: Synthesis, Properties, and Applications. Elsevier 出版社, ISBN: 978-0-323-91753-7.

科研论文 

14. Yuelin Fang, Susu Huang, Junjie Li*, Guangxi Zhai*, Lei Ye*, et al. Injectable Zwitterionic Physical Hydrogel with Enhanced Chemodynamic Therapy and Tumor Microenvironment Remodeling Properties for Synergistic Anticancer Therapy; (ACS Nano, 2023, 17, 24, 24883–24900, IF:17.1, Cover)

13. Rong Wang, Qiaoying Hu, Lei Ye*,Guangxi Zhai*, et al. Zwitterionic Injectable Hydrogel-Combined Chemo- and Immunotherapy Medicated by Monomolecular Micelles to Effectively Prevent the Recurrence of Tumor Post Operation； (ACS Applied Materials & Interfaces; 2024, DOI: 10.1021/acsami.3c17017; IF: 9.5)

12. Yabin Zhang, Tianyu Li, Luqing Zhang*, Lei Ye* et al. A highly sensitive and ultra-stretchable zwitterionic liquid hydrogel-based sensor as anti-freezing ionic skin; (Journal of Materials Chemistry A; 2022, 10, 3970, (Back cover); IF: 14.5)

11. Jin Li, Lei Ye*, Guangxi Zhai* et al. A novel liposome-loaded injectable hydrogel with enhanced treatment of choroidal neovascularization by sub-Tenon’s injection;(Materials Today Nano, 2022(20), 100264; IF:13.3)

10. Susu Huang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Zwitterionic biodegradable physical hydrogel based on ATRP technology for effective prevention of Postoperative Tissue Adhesion; (Materials & Design, 2023(227), 111727; IF:9.4)

9. Yuelin Fang, Yabin Zhang*, Guangxi Zhai*, Lei Ye*, et al. Salt Sensitive Purely Zwitterionic Physical Hydrogel for Prevention of Postoperative Tissue Adhesion;  (Acta Biomaterialia; 2023(158), 239; IF:10.6)

8. Yibin Chen, Lei Ye*, Yuanlu Cui*, et al. A novel inhalable quercetin-alginate nanogel as a promising therapy for acute lung injury; (Journal of Nanobiotechnology; 2022, 11;20(1):272. IF:9.4)

7. Huixian Yan, Lei Ye*, Guangxi Zhai* et al., A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy; (Biomaterials Science, 2022(10): 6583; IF: 7.59)

6. Qiu Na, Lei Ye*, Guangxi Zhai*, et al. A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases; (Journal of Nanobiotechnology; 2021, 19:428; IF:10.04)

5. Yuelin Fang, Lei Ye*, Guangxi Zhai*, et al. Research progress in tumor targeted immunotherapy; (Expert Opinion on Drug Delivery; 2021, 18(8):1067-1090; IF:8.1)

4. Rong Wang, Lei Ye*, Guangxi Zhai*, et al. Cancer targeted biomimetic drug delivery system;  (Journal of drug delivery science and technology; 2021, 63, 2065; IF:5.06)

3. Qirong Tong, Lei Ye*, Guangxi Zhai*, et al. Research Progress in Bioinspired Drug Delivery Systems; (Expert Opinion on Drug Delivery, 2020, 17(9):1269-1288; IF:8.1)

2. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Zwitterionic-modified starch-based stealth micelles for prolonging circulation time and reducing macrophage response; (ACS Applied Materials & Interfaces; 2016, 8, 4385-4398; IF: 10.3)

1. Lei Ye, Yabin Zhang, Fanglian Yao*, et al. Physical crosslinking starch-based zwitterionic hydrogel exhibiting excellent biodegradability, protein resistance and cytocompatibility; (ACS Applied Materials & Interfaces; 2016, 8, 15710-15723; IF: 10.3)

专利

1. 叶磊，翟光喜，黄苏苏，方跃霖；一种基于两性离子改性多糖的物理凝胶及其制备方法；国家发明专利；申请号：202210773927.3