基本信息

职称：教授

邮箱：[email protected]; [email protected] ;

地址：复旦大学生命科学学院A103室

个人简介

分子微生物学家，中国科学院院士，发展中国家科学院院士，美国微生物科学院院士。现任复旦大学生命科学学院微生物学和免疫学系主任，中科院上海营养与健康研究所生物医学大数据中心首席科学家，中科院深圳先进技术研究院合成生物学研究所首席科学家，中科院分子植物科学卓越创新中心合成生物学重点实验室专家委员会主任，山东大学公共卫生学院健康医疗大数据研究院/国家健康医疗大数据研究院首席科学家；兼任中国生物工程学会合成生物学专业委员会主任，上海生物工程学会名誉理事长。

主要研究方向

研究领域涉及微生物基因组学、系统与合成生物学以及生物信息学等方面。曾参与启动中国人类基因组计划及相关生命“组学”研究，克隆若干遗传病致病基因；主持若干重要微生物的基因组、功能基因组、比较和进化基因组研究，解析SARS冠状病毒分子进化机制。在细菌蛋白质乙酰化组和肠道微生物组等领域作出若干开创性工作。组建并领导中科院合成生物学重点实验室，在酵母染色体重构，代谢组与代谢流量组研究，天然化合物细胞工厂制造，基因编辑技术研发等方向上，实现重要突破。近年来，参与组建并领导中国科学院上海生命科学研究院（现营养与健康研究所）生物医学大数据中心，为建设国家生物医学大数据综合性服务平台开展预研工作。

代表性文章

1. W. Dong et al., Mycobacterial fatty acid catabolism is repressed by FdmR to sustain lipogenesis and virulence. Proc Natl Acad Sci U S A 118,(2021).

2. W. Tan et al., A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation. J Biol Chem 295, 5051-5066 (2020).

3. P. Li, H. Zhang, G. P. Zhao, W. Zhao, Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor. Nucleic Acids Res 48, 4902-4914 (2020).

4. T. Liao, Y. Wei, M. Luo, G. P. Zhao, H. Zhou, tmap: an integrative framework based on topological data analysis for population-scale microbiome stratification and association studies. Genome Biol 20, 293 (2019).

5. S. Y. Li et al., CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA. Cell Res 28, 491-493 (2018).

6. S. Y. Li et al., CRISPR-Cas12a-assisted nucleic acid detection. Cell Discov 4, 20 (2018).

7. C. Lei et al., The CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitro. Nucleic Acids Res 45, e74 (2017).

8. G. Liu et al., Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes. Sci Rep 3, 1569 (2013).

9. B. Zhang et al., An efficient procedure for marker-free mutagenesis of S. coelicolor by site-specific recombination for secondary metabolite overproduction. PLoS One 8, e55906 (2013).

10. S. Hu et al., Comparative genomic and transcriptomic analysis revealed genetic characteristics related to solvent formation and xylose utilization in Clostridium acetobutylicum EA 2018. BMC Genomics 12, 93 (2011).

11. P. Hao et al., Complete sequencing and pan-genomic analysis of Lactobacillus delbrueckii subsp. bulgaricus reveal its genetic basis for industrial yogurt production. PLoS One 6, e15964 (2011).

12. Y. X. Wei et al., Complete genome sequence of Bifidobacterium longum JDM301. J Bacteriol 192, 4076-4077 (2010).

13. C. Zhang et al., Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice. ISME J 4, 232-241 (2010).

14. Q. Wang et al., Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science 327, 1004-1007 (2010).

15. X. Ou, B. Zhang, L. Zhang, G. Zhao, X. Ding, Characterization of rrdA, a TetR family protein gene involved in the regulation of secondary metabolism in Streptomyces coelicolor. Appl Environ Microbiol 75, 2158-2165 (2009).

16. Z. Y. Zhang et al., Complete genome sequence of Lactobacillus plantarum JDM1. J Bacteriol 191, 5020-5021 (2009).

17. M. Li et al., Symbiotic gut microbes modulate human metabolic phenotypes. Proc Natl Acad Sci U S A 105, 2117-2122 (2008).

18. S. X. Ren et al., Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature 422, 888-893 (2003).