基本信息

姓名：候晔

职称：研究员

电子邮箱： [email protected]

教育经历

2013/09–2019/06，华中农业大学，动物遗传育种与繁殖，博士；

2016/10-2017/04，美国宾夕法尼亚州立大学，访问学者；

2009/09–2013/07，西北农林科技大学，动物科学，学士。

工作经历

2023/9-至今，获内蒙古大学“骏马计划”人才引进，任内蒙古大学生物医学研究院研究员；

2020/02-2023/05，美国西北大学芬伯格医学院，博士后；

研究方向

肿瘤的3D表观基因组学研究及单细胞3D表观基因组学新技术开发：利用表观及3D基因组学技术，尤其是单细胞多组学技术（包括single-cell RNA-seq、  single-cell ATAC-seq、single-cell CUT&Tag、 single-cell Hi-C等）发现肿瘤中单细胞层面表观和3D基因组的潜在新调控，并鉴定肿瘤标志物为肿瘤靶向治疗提供潜在的分子机制。

代表性论文

1. Zhao Y*, Hou Y*, Xu Y*, Luan Y, Zhou H, Qi X, Hu M, Wang D, Wang Z, Fu Y, Li J, Zhang S, Chen J, Han J, Li X #, Zhao S # (2021). A compendium and comparative epigenomics analysis of cis-regulatory elements in the pig genome. Nature Communications, 12(1), 2217.

2.Wang J*, Huang TY*, Hou Y*, Bartom, E., Lu X, Shilatifard A, Yue F#, Saratsis A# (2021). Epigenomic landscape and 3D genome structure in pediatric high-grade glioma. Science Advances, 7(23).

3.Iyyanki T*, Zhang B*, Wang Q*, Hou Y*, Jin Q, Xu J, Yang H, Liu T, Wang X, Song F, Luan Y, Yamashita H, Chien R, Lyu H, Zhang L, Wang L, Warrick J, Raman JD., Meeks JJ, DeGraff DJ#, Yue F# (2021). Subtype-associated epigenomic landscape and 3D genome structure in bladder cancer. Genome Biology, 22(1), 105.

4. Hou Y, Hu M, Zhou H, Li C, Li X, Liu X#, Zhao Y#, Zhao S(2018). Neuronal Signal Transduction- Involved Genes in Pig Hypothalamus Affect Feed Efficiency as Revealed by Transcriptome Analysis. Biomed Research International, 2018, 5862571.

5. Hou Y, Fu L, Li JJ, Li JX, Zhao Y, Luan Y, Liu A, Liu H, Li X, Zhao S, Li C#(2018). Transcriptome Analysis of Potential miRNA Involved in Adipogenic Differentiation of C2C12 Myoblasts. Lipids, 53(4), 375-386.

6.Wang X, Xu J, Zhang B, Hou Y, Song F, Lyu H, Yue F# (2021). Genome-wide detection of enhancer-hijacking events from chromatin interaction data in rearranged genomes. Nature Methods, 18(6), 661-668.

7. Xu J*, Song F*, Lyu H, Kobayashi M, Zhang B, Zhao Z, Hou Y, Wang X, Luan Y, Jia B, Stasiak L, Wong J, Wang Q, Jin Q, Qi J, Fu Y, Yang H, Hardison RC, Dovat S, Platanias LC, Diao Y, Yang Y, Yamada T, Viny AD, Levine RL, Claxton D, Broach JR, Zheng H#, Yue F# (2022). Subtype-specific 3D genome alteration in acute myeloid leukaemia. Nature, 2022 Nov;611(7935):387-398.