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The Cancer Imaging Archive hosts pathology images from the聽National Lung Screening Trial, in addition to the existing聽radiology images and a subset of the full clinical data.聽 If you need the full clinical data,please visit the聽Cancer Data Access System (CDAS) system. 聽The NLST was conducted by two separate networks of screening centers: 1)聽Lung Screening Study Network (LSS):10 centers and 34,612 participants; and 2)聽American College of Radiology Imaging Network (ACRIN): 23 centers and 18,840 participants.聽TCIA only hosts pathology data from LSS. The聽ACRIN pathology images and data are not available through TCIA.

As part of the pathology collection effort tissue, images, and data was obtained from 463 lung cancer patients (out of 1,284 total lung cancer patients in LSS).聽 Note that nine of these 463 participants had two primary lung tumors; these are accessible through TCIA as an optional additional download for these nine participants.聽

The NLST pathology specimen collection consists of biospecimens, images, and data for research.聽 Near the conclusion of NLST activities, all available blocks of preserved lung tissue from NLST lung cancer patients were requested from pathology labs.聽 Tissue cores were sampled from these donor blocks and placed into tissue microarrays (TMAs) and into Eppendorf tubes for analysis by the research community; the request process for the tissue specimens is under development as of October 2013.聽The images were obtained as an intermediate step in TMA construction.聽聽A thin section was cut from each donor tissue block, stained with hematoxylin and eosin (H & E), and imaged using an Aperio ScanScope.

A summary of the National Lung Screening Trial and its available datasets are provided on the聽Cancer Data Access System (CDAS). CDAS is maintained by Information Management System (IMS), contracted by the National Cancer Institute (NCI) as keepers and statistical analyzers of the NLST trial data.聽 The full clinical data set from NLST is available through CDAS.聽 Users of TCIA can download without restriction a publicly distributable subset of that clinical data, along with the CT and Histopathology images collected during the trial.聽 (These previously were restricted.)