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data-id="" iid="">PubMedhttps://pubmed.ncbi.nlm.nih.gov/29095982Dose-Dependent Effects of Intranasal Insulin on Resting-State …网页2018年1月1日 · Dose-dependent spillover of nasal insulin into the bloodstream was detected. The brain response was not correlated with this temporary rise in circulating insulin. Conclusions: Nasal insulin dose-dependently modulated regional brain activity with the strongest effects after 160 U. However, this dose was accompanied by a transient …
发布时间:2024-07-11data-id="" iid="">PubMedhttps://pubmed.ncbi.nlm.nih.gov/30274984Targeting Resistance against the MDM2 Inhibitor RG7388 in ... - PubMed网页2019年1月1日 · Purpose: Resistance is an obstacle of glioma therapy. Despite targeted interventions, tumors harbor primary resistance or become resistant over short course of treatment. This study examined the mouse double minute 2 (MDM2) inhibitor RG7388 together with radiotherapy and analyzed strategies to overcome acquired MDM2 inhibitor …
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