花晓琳

聚焦高危妊娠对母儿结局的影响的研究，针对子痫前期这一妊娠期严重并发症，进行深入的机制研究，为子痫前期新的潜在治疗靶点提供理论依据。长期从事应用组织工程治疗盆底疾病的研究，致力于应用骨髓间充质干细胞（BMSCs）治疗早期盆底脱垂和盆腔脏器的损伤修复等相关机制和临床研究；

Professor Hua has been long engaged in explorations in tissue engineering for pelvic floor dysfunctions. She has been working on the application and the mechanism of bone marrow mesenchymal stem cells (BMSCs) in the treatment of early pelvic floor prolapse and pelvic organ damage, and achieved a more effective treatment than traditional methods. She has also focused on the impact of high-risk pregnancy on maternal and neonatal outcomes. Her in-depth mechanistic and clinical research has made many contributions to the pathogenesis and treatment of preeclampsia, one of the serious pregnancy complications, and provided a theoretical basis for potential therapeutic targets for preeclampsia.

作为项目负责人，主持包括3项国家自然科学基金在内的多项科研基金，近年来以第一作者或通讯作者发表论文43篇，其中SCI论文34篇，最高影响因子9.1分，累计影响因子141.4分。

As the project leader, Professor Hua has hosted a number of scientific research projects, including 3 National Natural Science Foundation of China. She has published 43 papers as the first/corresponding author in recent years, including 34 SCI papers with a total IF of 141.4 in which the highest IF is 9.1.

1.近年来主持的科研项目

Projects that Professor Hua hosted in recent years are listed as follows：

1) 搭载ESO的蜕膜巨噬细胞靶向的BMSCs-Exos在治疗子痫前期中的作用研究，上海市卫健委卫生健康学科带头人（2022XD004），经费45万，2023.1～2025.12，在研，主持；

2) 应用AI眼底检查建立子痫前期高危人群的新筛查方法的临床研究，上海市第一妇婴保健院“人才蓄水池”领航计划，经费60万，2022.12～2025.11，在研，主持；

3) 早期超声诊断产后盆底损伤并进行早期康复训练对防治PFD的作用的研究，浦东医联体项目（PDYLT2022-15），经费10万，2022.8～2023.7，在研，主持；

4) LncRNA-DIO3OS编码的新型小分子功能肽调控JAM2治疗盆底功能障碍性疾病的作用和机制研究，国家自然科学基金（82071629），经费52万，2021.1～2024.12，在研，主持；

5) 人工智能眼底识别技术在妊娠期高血压疾病的开发与应用研究，上海市卫健委卫生行业临床研究专项基金（202040128），经费10万，2021.1～2023.12，在研，主持；

6) 雌激素作用下BMSCs结合改性PRP水凝胶支架的设计及其在子宫内膜损伤修复障碍中的应用，国家自然科学基金（81873816），经费57万，2019.1～2022.12，已结题，主持；

7) 质子泵抑制剂抑制胎盘滋养细胞外泌体分泌调控血管内皮功能治疗子痫前期的实验研究，浦东卫健委联合攻关课题（PW2019D-13），经费30万，2019.11～2022.10，已结题，主持

8) 评价“超高龄”妊娠对母儿结局的影响及不同产前诊断技术在诊断和干预出生缺陷中的作用，上海市卫计委课题（201640366），经费10万元，2017.1～2019.12，已结题，主持；

9) 微囊化VEGF缓释系统转染BMSCs治疗子宫内膜损伤的实验研究，上海交通大学“医工交叉”面上项目（YG2016MS71），经费21万元，2017.1～2019.12，已结题，主持；

10) elastin基因修饰的BMSCs在bFGF纳米缓释系统诱导下注射治疗盆底功能障碍性疾病的实验研究，国家自然科学基金（81401186），经费23万元，2015.1～2017.12，已结题，主持；

11) 组织工程纳米可吸收补片重建盆底功能的研究，上海市卫生局青年科研项目（20114y079），经费4万元，2012.1～2014.12，已结题，主持;

12) 可吸收纳米生物补片重建盆底功能的实验研究，上海交通大学医工交叉青年研究基金（YG2011MS33），经费10万元， 2012.1～2013.12，已结题，主持。

2. 近年来以第一作者或通讯作者发表论文43篇，其中SCI论文34篇，具体如下：

1） Peng J#, Chen Y#, Wan S, Zhou T, Chang YS, Zhao X*, Hua X*. Predictors for histological chorioamnionitis among women with preterm prelabour rupture of membranes after dexamethasone treatment: a retrospective study. BJOG . 2023 Feb 20. doi: 10.1111/1471-0528.17431. Online ahead of print. (IF 5.8)

2）Dong L#, Qin S#, Che R, Pei J, Hua X*. Successful pregnancy in the blind hemicavity of Robert's uterus: a rare case report and brief literature review. BMC Pregnancy Childbirth. 2023 Mar 28;23(1):211. (IF 3.1)

3）Wan S#, Zhou T#, Che R#, Li Y#, Peng J, Wu Y, Gu S, Cheng J*, Hua X*. CT-based machine learning radiomics predicts CCR5 expression level and survival in ovarian cancer. J Ovarian Res. 2023 Jan 3;16(1):1. doi: 10.1186/s13048-022-01089-8. (IF 4.0)

4）Yang Q#, Zhou CC#, Chen Y, Pei JD, Hua XL*, Yao LP*. Prediction model for successful induction of labor by cervical strain elastography diagnosed at late-term pregnancy in nulliparous women. BMC Pregnancy Childbirth. 2023 Feb 14;23(1):114. doi: 10.1186/s12884-023-05426-7. (IF 3.1)

5）Y Chen#, S Wan#, C Zhou, S Gu, T Zhou, L Yao, J Pei* and X Hua*. Exosomes Derived from miR-195-5p Transfected Bone Marrow Mesenchymal Stem Cells Alleviate Pelvic Floor Dysfunction in Rats. Adv Ther. 2023 Feb. doi:org/10.1002/adtp.202200192.（IF 3.8）

6）Wu Y#, Pei J#, Dong L#, Zhou Z, Zhou T, Zhao X, Che R, Han Z, Hua X*. Association Between Maternal Weight Gain in Different Periods of Pregnancy and the Risk of Venous Thromboembolism: A Retrospective Case–Control Study. Frontiers in Endocrinology. 2022 Jul 18;13:858868. doi: 10.3389/fendo.2022.858868. eCollection 2022. (IF 5.2)

7）Zhou C#, Wan S#, Zhao X#, Gu S, Pei J, Wu Y, Han Z, Che R*, Hua X*. Exosomal miR-195 in hUC-MSCs alleviates hypoxia-induced damage of trophoblast cells through tissue factor pathway inhibitor 2. Curr Res Transl Med. 2022 Sep;70(4):103352. doi: 10.1016/j.retram.2022.103352. Epub 2022 Aug 5.(IF 4.1)

8）Gu S#, Pei J#, Zhou C, Zhao X, Wan S, Zhang J, Adanlawo A, Luo Z, Wu G*, Hua X*. Selective versus routine use of episiotomy for vaginal births in Shanghai hospitals, China: a comparison of policies. BMC Pregnancy Childbirth. 2022 Jun 11;22(1):475. doi: 10.1186/s12884-022-04790-0. (IF 3.1)

9）Wan S#, Zhao X#, Niu Z, Dong L, Wu Y, Gu S, Feng Y*, Hua X*. Influence of ambient air pollution on successful pregnancy with frozen embryo transfer: A machine learning prediction model. Ecotoxicol Environ Saf. 2022 May 1;236:113444. doi: 10.1016/j.ecoenv.2022.113444. Epub 2022 Mar 31. (IF 6.8)

10）Gu S#, Zhou C#, Pei J#, Wu Y, Wan S, Zhao X, Hu J, Hua X*. Esomeprazole inhibits hypoxia/endothelial dysfunction–induced autophagy in preeclampsia. Cell Tissue Res; 2022 Apr;388(1):181-194. doi: 10.1007/s00441-022-03587-z. Epub 2022 Jan 29. (IF 3.6)

11）Wan S#, Zhao X#, Pei J#, Han Z, Che R, Qin S, Hua X*. Association of age at benign hysterectomy with leukocyte telomere length in a nationally representative population. Maturitas. 2022 May;159:46-51. doi: 10.1016/j.maturitas.2022.01.002. Epub 2022 Jan 11. (IF 4.9)

12）Wan S#, Yang M#, Pei J, Zhao X, Zhou C, Wu Y, Sun Q, Wu G*, Hua X*. Pregnancy outcomes and associated factors for uterine rupture: an 8 years population-based retrospective study. BMC Pregnancy Childbirth; 2022 Feb 1;22(1):91. doi: 10.1186/s12884-022-04415-6. (IF 3.1)

13）Yao LP#, Yang Q#, Pei JD, Wu YL, Wan S, Chen ZQ, Hua XL*. Ultrasound-Indicated Cervical Cerclage Efficacy Between 16 and 28 Weeks of Gestation in Twin Pregnancy: Retrospective Cohort Study. Int J Gen Med. 2022 Mar 2;15:2377-2387. doi: 10.2147/IJGM.S341155. eCollection 2022. (IF 2.3)

14）Hutchinson N#, Wu Y#, Wang Y#, Kanungo M, DeBruine A, Kroll E, Gilmore D, Eckrose Z, Gaston S, Matel P, Kaltchev M, Nickel AM, Kumpaty S, Hua X*, Zhang W*. Green Synthesis of Gold Nanoparticles Using Upland Cress and Their Biochemical Characterization and Assessment. Nanomaterials (Basel). 2021 Dec 23;12(1):28. doi: 10.3390/nano12010028. (IF 5.3)

15）Jindan Pei, Yan Li, Zhihong Min, Qi Dong, Jiali Ruan, Juan Wu, Xiaolin Hua*. MiR-590-3p and its targets VEGF, PIGF, and MMP9 in early, middle, and late pregnancy: their longitudinal changes and correlations with risk of fetal growth restriction. Ir J Med Sci. 2022 Jun;191(3):1251-1257. doi: 10.1007/s11845-021-02664-6. Epub 2021 Jun 22. Online ahead of print. (IF 2.1)

16）Che R#, Pei J#, Chen H, Dong L, Wu Y, Hua X*. The influence of hypertensive disorders during pregnancy on the perinatal outcome of different chorionic twins. J Matern Fetal Neonatal. 2022 Dec;35(25):7146-7152. doi: 10.1080/14767058.2021.1945574. Epub 2021 Jun 27. (IF 1.8)

17）Wu Y#, Wan S#, Gu S, Mou Z, Dong L, Luo Z, Zhang J*, Hua X*. Gestational weight gain and adverse pregnancy outcomes: a prospective cohort study. BMJ Open. 2020 Sep 2;10(9):e038187. doi: 10.1136/bmjopen-2020-038187. (IF 2.9)

18）Zhou Y#, Shen H#, Wu Y, Zhao X, Pei J, Mou Z, Dong J, Hua X*. Platelet-Rich Plasma Therapy Enhances the Beneficial Effect of Bone Marrow Stem Cell Transplant on Endometrial Regeneration. Front Cell Dev Biol. 2020 Feb 21;8:52. doi: 10.3389/fcell.2020.00052. eCollection 2020. (IF 5.5)

19）Yang MN#, Zhang GH#, Du K, Wang WJ, Dong Y, He H, Chiu HC, Guo YN, Ouyang F, Zhang J, Hua X*, Luo ZC*. Retinol-binding protein 4, fetal overgrowth and fetal growth factors. Pediatr Res. 2020 Apr;87(5):946-951. doi: 10.1038/s41390-019-0685-0. Epub 2019 Nov 30. (IF 3.6)

20）Yang MN#, Chiu HC#, Wang WJ, Fang F, Zhang GH, Zhu H, Zhang L, Zhang DL, Du Q, He H, Huang R, Liu X, Li F, Zhang J, Ouyang F, Xiaolin Hua*, Zhong-Cheng Luo*. Sex dimorphism in the associations of gestational diabetes with cord blood adiponectin and retinol-binding protein 4. BMJ Open Diabetes Res Care. 2020 Sep;8(1):e001310. doi: 10.1136/bmjdrc-2020-001310. (IF 4.1)

21）Shen H#, Jin M#, Gu S, Wu Y, Yang M, Hua X*. CD97 Is Decreased in Preeclamptic Placentas and Promotes Human Trophoblast Invasion Through PI3K/Akt/mTOR Signaling Pathway. Reprod Sci. 2020 Aug;27(8):1553-1561. doi: 10.1007/s43032-020-00183-w. (IF 2.9)

22）Yusen Ding#, Yan Wang#, Yanjie Su, Zhi Yang, Jiaqiang Liu*, Xiaolin Hua*, Hao Wei*. A novel channel-wall engineering strategy for two-dimensional cationic covalent organic frameworks: Microwave-assisted anion exchange and enhanced carbon dioxide capture. Chinese Chemical Letters. 2020 Jan;31(1):193-196. doi: 10.1016/j.cclet.2019.05.012. (IF 9.1)

23）Gu S#, Shen H#, Zhou Y, Ni J, Zheng T, Mou Z, Hua X*. Tetramethylpyrazine reduces the consequences of nitric oxide inhibition in pregnant rats. J Cell Physiol. 2019 Nov;234(11):19799-19806. doi: 10.1002/jcp.28579. Epub 2019 Apr 1. (IF 5.6)

24）Wu Y#, Chen Y#, Shen M, Guo Y, Wen SW, Lanes A, White RR, Adanlawo A, Walker M*, Hua X*. Adverse maternal and neonatal outcomes among singleton pregnancies in women of very advanced maternal age: a retrospective cohort study. BMC Pregnancy Childbirth. 2019 Jan 3;19(1):3. doi: 10.1186/s12884-018-2147-9. (IF 3.1)

25）Stealey S, Guo X, Ren L, Bryant E, Kaltchev M, Chen J, Kumpaty S, Hua X*, Zhang W*. Stability improvement and characterization of bioprinted pectin-based scaffold. J Appl Biomater Funct Mater. 2019 Jan-Mar;17(1):2280800018807108. doi: 10.1177/2280800018807108. (IF 2.5)

26）Hua X#, Shen M#, Reddy UM, Buck Louis G, Souza JP, Gülmezoglu AM, Zhang J*. Comparison of the INTERGROWTH-21st, National Institute of Child Health and Human Development, and WHO fetal growth standards. Int J Gynaecol Obstet. 2018 Nov;143(2):156-163. doi: 10.1002/ijgo.12637. Epub 2018 Aug 30. (IF 3.8)

27）Wang L#, Yang M#, Jin M, Wu Y, Zheng T, Gu S, Hua X*. Transplant of insulin-like growth factor-1 expressing bone marrow stem cells improves functional regeneration of injured rat uterus by NF-κB pathway. J Cell Mol Med. 2018 May;22(5):2815-2825. doi: 10.1111/jcmm.13574. Epub 2018 Mar 7. (IF 5.3)

28）Jin M#, Wu Y#, Wang J, Ye W, Wang L, Yin P, Liu W, Pan C, Hua X*. MicroRNA-29 facilitates transplantation of bone marrow-derived mesenchymal stem cells to alleviate pelvic floor dysfunction by repressing elastin. Stem Cell Res Ther. 2016 Nov 17;7(1):167. doi: 10.1186/s13287-016-0428-7. (IF 7.5)

29）Jin M#, Chen Y#, Zhou Y, Mei Y, Liu W, Pan C, Hua X*. Transplantation of bone marrow-derived mesenchymal stem cells expressing elastin alleviates pelvic floor dysfunction. Stem Cell Res Ther. 2016 Apr 5;7(1):51. doi: 10.1186/s13287-016-0308-1. (IF 7.5)

30）Hua X#, Zhang J#, Guo Y, Shen M, Gaudet L, Janoudi G, Walker M, Wen SW*. Effect of folic acid supplementation during pregnancy on gestational hypertension/preeclampsia: A systematic review and meta-analysis. Hypertens Pregnancy. 2016 Nov;35(4):447-460. doi: 10.1080/10641955.2016.1183673. Epub 2016 Jun 17. (IF 1.5)

31）Jin M#, Yang Z#, Ye W, Yu X, Hua X*. Prognosis significance of Histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma. Oncol Lett. 2015 Aug;10(2):857-862. doi: 10.3892/ol.2015.3319. Epub 2015 Jun 4. (IF 2.9)

32）Jin M#, Yang Z#, Ye W, Xu H, Hua X*. MicroRNA-150 predicts a favorable prognosis in patients with epithelial ovarian cancer, and inhibits cell invasion and metastasis. PLoS One. 2014 Aug 4;9(8):e103965. doi: 10.1371/journal.pone.0103965. eCollection 2014. (IF 3.7)

33）Hua X, Zeng Y, Zhang R, Wang H, Diao J, Zhang P*. Using platelet-rich plasma for the treatment of symptomatic cervical ectopy. Int J Gynecol Obstet. 2012 Oct;119(1):26-9. doi: 10.1016/j.ijgo.2012.05.029. Epub 2012 Jul 24. (IF 3.8)

34）Wu T#, Hua X#, He Z, Wang X, Yu X*, Ren W. The bactericidal and biocompatible characteristics of reinforced calcium phosphate cements. Biomed Mater. 2012 Aug;7(4):045003. doi: 10.1088/1748-6041/7/4/045003. Epub 2012 May 4. (IF 4.0)

35）邵飞雪，董玲玲，周天凡，花晓琳*. 血浆纤维蛋白原在妊娠并发症中的研究进展. 实用妇产科杂志，2023，39（4）：268-271

36）周天凡,姚莉萍,顾盛奕,花晓琳*.E3泛素连接酶和小泛素蛋白样修饰蛋白在子痫前期发病机制中的研究进展. 同济大学学报(医学版)，2022,43(6):875-882. doi: 10.12289/j.issn.1008-0392. 22152

37）车荣华，裴锦丹，万盛，李花，花晓琳*. 肺栓塞产妇临床高危因素及生物指标分析. 同济大学学报(医学版)，2022,43(1):63-69. doi: 10.12289/j.issn.1008-0392.21152

38）杨梦楠,刘明,王磊,王伟鹏，伍岳琳，裴锦丹，万盛，杨洁，王俊,花晓琳*.多因素联合预测先天性膈疝胎儿的生存. 中华围产医学杂志，2021,24(9):665-670. doi: 10.3760/cma.j.cn113903-20210219-00148

39）曾嫣，伍岳琳，沈华祥，杨梦楠，顾盛奕，牟正骞，花晓琳*. 多学科管理下鸟氨酸氨甲酰基转移酶缺乏症妇女连续三次妊娠分娩健康儿一例. 中华围产医学杂志，2020，23(2):111-113. doi: 10.3760/cma.j.issn.1007-9408.2020.02.007

40）董玲玲，裴锦丹，车荣华，伍岳琳，花晓琳*. 妊娠合并急性胰腺炎42 例的临床特征及诊疗分析.同济大学学报(医学版)，2020，41(4):392-496. doi: 10.16118/j.1008－0392.2020.04.016

41）顾盛奕,金敏菲,花晓琳*.胎盘植入相关因子的研究进展.国际妇产科学杂志,2018,45(04):365-369.

42）杨梦楠，顾盛奕，王俊，花晓琳*.产前辅助检查对诊断先天性膈疝及其预后评价的研究进展.中华围产医学杂志，2018，21(08):895-898. doi: 10.3760/cma.j.issn.1007-9408.2018.08.008

43）梅艳，张萍，金敏菲，任岳琳，花晓琳*.妊娠相关B族链球菌感染的研究进展.中华围产医学杂志,2017,20(12):365-369. doi: 10.3760/cma.j.issn.1007-9408.2017.12.011