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Acupuncture has become a complementary alternative medical therapy that is used widely, and relevant high-quality randomized controlled clinical trials have been published in international journals frequently. However, the results are not identical. The control of influencing factors of acupuncture effect is one of the main reasons for the difference. From the perspective of acupoint selection, related parameters of acupuncture, and De qi, some factors affecting the curative effect are discussed. The principle of selecting acupoints, compatibility, and acupuncture prescription are specified, and cupuncture angle, depth, retention time, interval time, treatment course, and De qi are emphasized as well. Experience was therefore summarized. In the future, it is necessary to construct the optimal prescription of acupuncture for diseases, set appropriate acupuncture parameters, and ensure the sense of De qi of both doctors and patients during the operation of the acupuncture. Moreover, modern technology and instruments should be fully used to provide necessary objective data for the design of acupuncture research, so as to better serve clinical treatment.
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