刘长青

刘长青简介

刘长青，教授、博士，硕士生导师，省级教学名师，蚌埠医学院生命科学学院副院长，美国康涅狄格大学访问学者，安徽省细胞生物学会副秘书长。主要从事神经退行性疾病的病理机制与干细胞移植治疗。近年来，主持国家自然科学基金2项，国家科技部基础建设平台项目子课题1项，安徽省重点研究与开发计划项目1项，蚌埠医学院重大科技项目孵育计划1项，第一作者或通讯作者在《Int. J. Biol. Sci》、《Int. J. Mol. Sci》等期刊发表SCI论文32篇。获中国农业科学院科技成果一等奖1项，获安徽省教学成果二等奖1项（第1），校级一等奖1项（第1），安徽省教师教学创新大赛二等奖1项，参与编著国家标准1项，国家发明专利4项。主持省级质量工程项目6项，主编省级规划教材1部，指导大学生获国家级创新创业项目7项，国家级生命科学竞赛一等奖1项，三等奖1项，挑战杯省级二等奖2项。E-mail:[email protected].

主持研究课题

1. 国家自然科学基金面上项目，81771381，组合诱导CiPSCs-NSC与DA神经元前体移植治疗帕金森病模型猪体内功能建立及调控机制研究，2018.01-2021.12，54万元，主持；

2. 国家自然科学基金青年项目，81301333，无透明带核移植胚胎干细胞系移植治疗帕金森病分子机制的比较研究，2014.01-2016.12，23万元，主持；

3. 安徽省重点研究与开发计划项目，2022e07020030，CiPSCs-GABAergic对CiPSCs-dopaminergic神经元前体工程细胞移植治疗帕金森病协同效应的关键技术研究。2022.01-2024.12，30万元，主持；

4. 科技部国家科技基础条件平台子项目，TZDWZYK2019-09，工作犬体细胞库，2019-01至2020-12，10万元/年，主持；

5. 蚌埠医学院重大科技项目孵育计划，2021byfy002，CiPSCs-GABAergic对CiPSCs-dopaminergic神经元前体移植治疗帕金森病协同效应的分子机制研究。2022.01-2024.12，50万元，主持；

主持教研项目

1. 安徽省重大教研项目（2018jyxm1177），医学院校生物类专业“医理融通”培养模式相适应的高水平实践教学基地评估体系的创建与实践2019.01-2020.12，主持。

2. 生物科学省级一流本科专业，2020.01-2022.12，主持。

3. 生物医学省级一流本科人才示范引领基地建设项目（2019rcsfjd052），主持，2020.01-2022.12。

4. 生物医学科学专业省级教学团队，2021jxtd184，2022.01-2024.12，主持。

5. 省级创新创业实践教学中心，2021scsjzx008，2022.01-2024.12，主持。

6. 生物学省级特色学位点建设项目，2022tsxwd042，2023.01-2024.12, 主持。

代表性论文

1. Yu Guo, Yuan-Yuan Wang, Ting-Ting Sun, Jia-Jia Xu, Pan Yang, Cai-Yun Ma, Wei-Jun Guan, Chun-Jing Wang, Gao-Feng Liu, Chang-Qing Liu. Neural progenitor cells derived from fibroblasts induced by small molecule compounds under hypoxia for treatment of Parkinson’s disease in rats. Neural Regeneration Research, 2023,18(5):1090-1098.

2. Guo Y, Zhu H, Wang Y, Sun T, Xu J, Wang T, Guan W, Wang C, Liu C#, Ma C#. Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model. Cell Tissue Res. 2023. 391(3):425-440.

3. Jiajia Xu, Yangyang Li, Huan Zhu, Wenyu Wu, Yumeng Liu, YuGuo, Weijun Guan, Chang-Qing Liu and CAIYUN MA. Therapeutic function of a novel rat induced pluripotent stem cell line in a 6-OHDA-induced rat model of Parkinson’s disease. International Journal of Molecular Medicine. 2022, 50(6):140.

4. Guo Yu, Guan Yuhan, Zhu Huan, Sun Tingting, Wang Yuanyuan, Ma Caiyun, Rik Emery, Wang Chunjing, Liu Changqing#. Therapeutic function of iPSCs-derived primitive neuroepithelial cells in a rat model of Parkinson's disease, Neurochemistry International, 2022, 155: 105324.

5. Yu Guo, Huan Zhu, Xiangchen Li, Caiyun Ma, Tingting Sun, Chunjing Wang, Weijun Guan, Changqing Liu#. Multiple Functions of Reversine on the Biological Characteristics of Sheep Fibroblasts. Scientific Reports. 2021, 11:12365.

6. Yu Guo, Huan Zhu, Xiangchen Li, Caiyun Ma, Yanan Li, Tingting Sun, Chunjing Wang, Weijun Guan, Changqing Liu#. RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF-β1/Smad pathway. International Journal of Molecular Medicine. 2021, 48:148.

7. Ma C, Liu Y, Ma Y, Jiang L, Huang Q, Liu G, Guo Y, Wang C, Liu C#. Identification and characterization of pulmonary mesenchymal stem cells derived from rat fetal lung tissue. Tissue Cell. 2021, 73:101628.

8. Wang C, Li S, Ren H, Sheng Y, Wang T, Liu C﹟. Anti-Proliferation and Pro-Apoptotic Effects of Diosmetin via Modulating Cell Cycle Arrest and Mitochondria-Mediated Intrinsic Apoptotic Pathway in MDA-MB-231 Cells. Med SciMonit. 2019; 25:4639-4647.

9. Xiangchen Li, Yu Guo, Yaxin Yao, JinlianHua, Yuehui Ma, Changqing Liu#. Reversine Increases the Plasticity of Long-Term Cryopreserved Fibroblasts to Multipotent Progenitor Cells through Activation of Oct4. Int J Biol Sci. 2016; 12(1): 53–62.

10. Wang, C., Liao, Y., Wang, S., Wang, D., Wu, N., Xu, Q., &Liu, C#. Cytoprotective effects of diosmetin against hydrogen peroxide-induced L02 cell oxidative damage via activation of the Nrf2-ARE signaling pathway. Molecular Medicine Reports, 2018, 17(5), 7331-7338.

11. Ma Caiyun, Guo Yu, Wen Hebao, ZhengYanjie, Tan Leiqi, Guan Weijun#，Changqing Liu#. Identification and Multi-lineage potential research of a novel type of Adipose-derived Mesenchymal Stem Cells from Goose Inguinal Groove. DNA and Cell biology, 2018, 37(9):731-741.

12. Caiyun Ma, Yu Guo, Hao Liu, Kunfu Wang, Jinjuan Yang, Xiangchen Li, Changqing Liu# and Weijun Guan#. Isolation and biological characterization of a novel type of pulmonary mesenchymal stem cells derived from Wuzhishan miniature pig embryo. Cell Biology International, 2016, 40: 1041–1049.

13. Liu Changqing, Bai Chunyu, Guo Y, Liu D, Guan WJ. Construction and Preliminary Characterization Analysis of Siberian tiger Bacterial Artificial Chromosome Library with approximately 6.5-fold genome equivalent coverage. International Journal of Molecular Sciences, 2018, 15: 4189-4200.

14. Changqing Liu*, Guo Y, Li XC, Ma YH, Guan WJ. Establishment and genetic characteristics analysis of in vitro culture a fibroblast cell line derived from Wuzhishan miniature pig. Cryobiology, 2014, 68:281-287.

15. Liu Changqing, Liu D, Guo Y, Lu T, Li X, Zhang M, Ma J, Ma Y, Guan W. Construction of a Full-Length Enriched cDNA Library and Preliminary Analysis of Expressed Sequence Tags from Bengal Tiger Pantheratigristigris. International Journal of Molecular Sciences, 2013, 4(6):11072-11083.

16. Chang-Qing Liu, Tao-Feng Lu, Dan Liu, Wei-Jun Guan, Yue-Hui Ma. Construction of cDNA library and preliminary analysis of expressed sequence tags from Siberian tiger. International Journal of Biological Sciences, 2010, 6(6):584-589.