活性氧（ROS）响应微球用于喜树碱的靶向药物递送,Journal of Drug Delivery Science and Technology

用于治疗癌症的药物的非选择性不可避免地导致快速分裂的正常健康细胞的破坏。为了克服该限制，已经报道了各种各样的靶向药物递送系统。其中，微粒药物递送是最有效的途径之一，并且对外部刺激缺乏响应性。为了克服该限制，开发了基于活性氧（ROS）敏感的吐温80包覆的磁性氧化铁纳米粒子的新药物递送系统。这项研究的基本原理是基于文献报道，癌细胞会以更高的浓度积累氧自由基。喜树碱喜树碱（CPT）被封装在PLGA-PVA磁性微球（CPT-MMSs）中，喜树碱在过氧化氢存在下的特异性释放证明了其对ROS的响应性。实验观察表明，与吐温80包被的磁性氧化铁纳米粒子（MIONs）和单独的CPT相比，CPT-MMS介导的人宫颈癌（HeLa）癌细胞具有更明显的细胞毒性。

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Non-selectivity of drugs used in the treatment of cancer inevitably leads to destruction of rapidly dividing normal healthy cells. In order to overcome this limitation a wide variety of targeted drug delivery systems have been reported. Among them, microparticulate drug delivery is a one of the most efficient routes and lacks responsiveness to external stimuli. In order to overcome this limitation a new drug delivery system based on reactive oxygen species (ROS) sensitive tween 80 coated magnetic iron oxide nanoparticles was developed. The rationale for this study is based on the literature reports that cancer cells accumulate oxygen free radicals at higher concentrations. The cancer chemotherapeutic agent camptothecin (CPT) was encapsulated in PLGA-PVA magnetic microspheres (CPT-MMSs) and its responsiveness to ROS was demonstrated by the specific release of camptothecin in the presence hydrogen peroxide. The experimental observations showed more marked cytotoxicity in human cervical cancer (HeLa) cancer cells mediated by CPT-MMSs as compared to tween 80 coated magnetic iron oxide nanoparticles (MIONs) and CPT alone.