王晓东

触觉是人类重要的感觉之一。通过触觉，我们得以感受丝绸的柔滑、麻布的粗糙，分辨纸张的厚薄、硬币的大小。母亲的爱抚可以让孩童倍感舒适和安全，握手和拥抱可以让双方感受到亲切和温暖。很多研究表明，正性触觉刺激可以促进认知发育、舒缓压抑情绪，而一些精神疾病患者往往存在触觉信息加工整合障碍。然而，触觉经历如何调节大脑发育与可塑性，进而调节认知和情绪？触觉与其它感官信息（如视觉、听觉、嗅觉）的整合如何影响大脑与行为？单模态或跨模态感觉信息加工整合异常又如何参与应激相关精神疾病的发生发展？

王晓东课题组结合行为学、活动神经元标记、化学遗传学、神经环路示踪和深度学习等技术，旨在探索跨模态感觉整合与应激相关精神疾病的关系。我们欢迎感兴趣的同学加盟！

课题组近五年代表性工作：

Wang C#, Liu H#, Li K#, Wu ZZ, Wu C, Yu JY, Gong Q, Fang P, Wang XX, Duan SM, Wang H, Gu Y, Hu J, Pan BX, Schmidt MV, Liu YJ, Wang XD* (2020). Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis. Nature Communications 11, 6045.

Liu YJ*, Zhang T, Cheng D, Yang J, Chen S, Wang X, Li X, Duan D, Lou H, Zhu L, Luo J, Ho MS*, Wang XD*, Duan S* (2020). Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD. Science Advances 6, eaba5783.

Yu JY, Fang P, Wang C, Wang XX, Li K, Gong Q, Luo BY, Wang XD* (2018). Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits. Neuropharmacology 135, 474-486.

Gong Q, Su YA, Wu C, Si TM, Deussing JM, Schmidt MV, Wang XD* (2018). Chronic stress reduces nectin-1 mRNA levels and disrupts dendritic spine plasticity in the adult mouse perirhinal cortex. Frontiers in Cellular Neuroscience 12, 67.

Li K#, Shen S#, Ji YT, Li XY, Zhang LS, Wang XD* (2018). Melatonin augments the effects of fluoxetine on depression-like behavior and hippocampal BDNF-TrkB signaling. Neuroscience Bulletin 34, 303-311.

Li JT#, Xie XM#, Yu JY, Sun YX, Liao XM, Wang XX, Su YA, Liu YJ, Schmidt MV, Wang XD*, Si TM* (2017). Suppressed calbindin levels in hippocampal excitatory neurons mediate stress-induced memory loss. Cell Reports 21, 891-900.

Wang XX, Li JT, Xie XM, Gu Y, Si TM, Schmidt MV, Wang XD* (2017) Nectin-3 modulates the structural plasticity of dentate granule cells and long-term memory. Translational Psychiatry 7, e1228.

Yang XD, Liao XM, Uribe-Marino A, Liu R, Xie XM, Jia J, Su YA, Li JT, Schmidt MV, Wang XD*, Si TM* (2015). Stress during a critical postnatal period induces region-specific structural abnormalities and dysfunction of the prefrontal cortex via CRF1. Neuropsychopharmacology 40, 1203-1215.

多模态环境丰富模型：

单模态触觉丰富模型

研究员、博士生导师

地址 :  医学院科研楼A407

电话 :  0571-88208506

E-mail :  [email protected]

实验室网站  :

研究方向  :  应激与精神疾病