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FOXE1 - forkhead box E1 Gene
基因
蛋白
疾病
相关产品
直系同源
中文名称：叉头盒 E1 种属: Homo sapiens 同用名: TTF2; FOXE2; HFKH4; HFKL5; NMTC4; TITF2; TTF-2; FKHL15 基因 ID: 2304 | 基因类型: protein coding 关于 FOXE1 Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:97,853,226-97,856,717 (from NCBI)This gene has 1 transcript (splice variant), 168 orthologues, 42 paralogues and is associated with 7 phenotypes. 功能概要这种无内含子的基因编码一种属于转录因子叉头家族的蛋白质。该家族的成员包含一个保守的 100 个氨基酸的 DNA 结合“叉头”结构域。编码的蛋白质作为甲状腺转录因子发挥作用，在甲状腺形态发生中发挥作用。该基因的突变与 Bamforth-Lazarus 综合征相关，并且易患非髓样甲状腺癌 4。[RefSeq 提供，2016 年 11 月] This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016] FOXE1 基因产物(1) mRNA Protein Name NM_004473.4 NP_004464.2 forkhead box protein E1 FOXE1 蛋白结构 ForkheadForkhead: Forkhead domain (53 - 148) 0 100 200 300 373 a.a. 蛋白主名 其他名称forkhead box protein E1 HNF-3/fork head-like protein 5 关联疾病 疾病名称 别名 Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft PalateBamforth-Lazarus Syndrome Bamforth Syndrome Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome Hypothyroidism-Cleft Palate Syndrome BLS Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate Thyroid Cancer, Nonmedullary, 4NMTC4 Thyroid Cancer, Non-Medullary, 4 Cancer, Thyroid, Nonmedullary, Type 4 Familial Papillary Or Follicular Thyroid CarcinomaFnmtc Familial Pure Nonmedullary Thyroid Carcinoma Familial Nonmedullary Thyroid Gland Carcinoma Choanal Atresia, PosteriorChoanal Atresia Atresia Of Nares Posterior Choanal Atresia PCA Imperforate Nares Choanal Fusion Congenital Stenosis Of Nares Congenital Stenosis Of Choanae Nasal Atresia Nos Athyreosis Congenital HypothyroidismCretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos Cleft Lip/Palate-Ectodermal Dysplasia SyndromeOrofacial Cleft 7 Zlotogora-Ogur Syndrome CLPED1 Ectodermal Dysplasia, Margarita Island Type Ed4 Cleft Lip-Palate-Ectodermal Dysplasia Syndrome Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate Ectodermal Dysplasia 4 Ectodermal Dysplasia Margarita Type Ectodermal Dysplasia, Type 4 Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly Margarita Type Of Ectodermal Dysplasia Zlotogora-Zilberman-Tenenbaum Syndrome Ectd4 Ectodermal Dysplasia 4, Hair/Nail Type EDMI Ectodermal Dysplasia Type 4 Margarita Island Ectodermal Dysplasia Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate Non-Syndromic Orofacial Cleft 7 OFC7 Non-Syndromic Cleft Lip/Palate 7 Non-Syndromic Cleft Lip With Or Without Cleft Palate 7 Thyroid Malformation Differentiated Thyroid CarcinomaPapillary Or Follicular Thyroid Carcinoma Well-Differentiated Thyroid Carcinoma Differentiated Thyroid Gland Carcinoma Cleft Palate, IsolatedCleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate HypothyroidismThyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction Hypothyroidism, Congenital, Nongoitrous, 2Thyroid Dysgenesis CHNG2 Thyroid Hypoplasia Thyroid Hemiagenesis Thyroid Agenesis Athyreotic Hypothyroidism Rtsh Thyrotropin Resistance Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia Congenital Nongoitrous Hypothyroidism 2 Thyroid, Ectopic Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Hypothyroidism, Athyreotic Thyrotropin Resistance To Thyrotropin Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia Hypothyroidism, Congenital, Non-Goitrous, 2 Congenital Hypothyroidism Due To Thyroid Dysgenesis Thyroid-Stimulating Hormone Resistance Thyroid Ectopic Ectopic Thyroid Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome Hypothyroidism, Congenital, Nongoitrous, 1 Basal Cell CarcinomaBasal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site Diabetes Mellitus, Neonatal, With Congenital HypothyroidismNeonatal Diabetes Mellitus With Congenital Hypothyroidism Ndh Syndrome NDH Neonatal Diabetes-Congenital Hypothyroidism-Congenital Glaucoma-Hepatic Fibrosis-Polycystic Kidneys Syndrome Cleft LipCheiloschisis Labium Leporinum Cleft Lip, Unilateral, Complete Complete Unilateral Cleft Lip Hare Lip Congenital Fissure Of Lip Isolated Cleft Lip Cleft Lip Without Cleft Palate Cleft Lip Without Cleft Palate, Unilateral Isolated Cleft Lip, Unilateral Cleft Lip Without Cleft Palate, Bilateral Isolated Cleft Lip, Bilateral Van Der Woude SyndromeLip-Pit Syndrome Vws Cleft Lip And/Or Palate With Mucous Cysts Of Lower Lip Vdws Lps Lip Pit Syndrome Cleft Lip/Palate With Mucous Cysts Of Lower Lip Myopathy, Actin, Congenital, With Excess Of Thin Myofilaments Dicer1 SyndromePleuro-Pulmonary Blastoma Familial Tumor Susceptibility Syndrome Pleuropulmonary Blastoma Familial Tumor Susceptibility Syndrome Ppb Familial Tumor Susceptibility Syndrome Dicer1-Related Pleuropulmonary Blastoma Cancer Predisposition Syndrome Pleuro-Pulmonary Blastoma Familial Tumor Susceptibility Dicer1-Related Pleuropulmonary Blastoma Pleuropulmonary Blastoma Familial Tumor And Dysplasia Syndrome Pleuropulmonary Blastoma Family Tumor Susceptibility Syndrome Ppbftds Doid:0081063 Hypothyroidism, Congenital, Nongoitrous, 1Tsh Resistance CHNG1 Hypothyroidism Due To Tsh Receptor Mutations Thyrotropin Resistance Thyroid-Stimulating Hormone Rtsh Hypothyroidism Due To Unresponsiveness To Thyrotropin Congenital Nongoitrous Hypothyroidism 1 Thyroid-Stimulating Hormone, Resistance To Hypothyroidism, Nonautoimmune Hypothyroidism, Congenital, Due To Tsh Resistance Hypothyroidism, Congenital, Non-Goitrous, 1 Congenital Hypothyroidism Due To Tsh Resistance Non-Autoimmune Hypothyroidism Thyroid-Stimulating Hormone Resistance Hypothyroidism, Congenital, Nongoitrous, Type 1 Hypothyroidism, Congenital, Nongoitrous, 3 Thyroid Hormone Resistance Syndrome Thyroid Gland CancerThyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre Multinodular Goiter Popliteal Pterygium SyndromePPS Faciogenitopopliteal Syndrome Facio-Genito-Popliteal Syndrome Popliteal Web Syndrome Autosomal Dominant Popliteal Pterygium Syndrome Cleft Lip/Palate, Paramedian Mucous Cysts Of The Lower Lip, Popliteal Pterygium, Digital And Genital Anomalies Popliteal Pterygium Syndrome 1 Cleft Lip/Palate Paramedian Mucous Cysts Of The Lower Lip Popliteal Pterygium Digital And Genital Anomalies Popliteal Pterygium Orofacial CleftCleft, Orofacial Thyroid Gland DiseaseAbnormality Of The Thyroid Gland Thyroid Diseases Thyroid Gland Follicular CarcinomaFollicular Thyroid Carcinoma Follicular Adenocarcinoma Follicular Adenocarcinoma, Well Differentiated Follicular Carcinoma Thyroid Adenocarcinoma Adenocarcinoma, Follicular Carney Complex VariantCarney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV Pendred SyndromeGoiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness Thyroid Gland Anaplastic CarcinomaAnaplastic Thyroid Carcinoma Anaplastic Thyroid Cancer Thyroid Cancer, Anaplastic Thyroid Carcinoma, Anaplastic Thyroid Carcinoma Anaplastic 疾病名称 别名 Waldenstroem'S MacroglobulinemiaWaldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma 相关产品 Pre-clinical Phase 生物活性分子 (1) Cat. No. 产品名 作用方式 纯度 是否罕见病 HY-RS05047 FOXE1 Human Pre-designed siRNA Set A / 否 直系同源 种属 基因名 来源 基因 ID Macaca mulatta FOXE1 VGNC VGNC:72697 Bos taurus FOXE1 VGNC VGNC:29083 Felis catus FOXE1 VGNC VGNC:102929 Rattus norvegicus FOXE1 RGD RGD:621723 Mus musculus FOXE1 MGD MGI:1353500 Compound Screening Libraries 实体化合物库 Virtual Screening 虚拟筛选 Customize Your Library 定制专属化合物库 Drug Screening Service 药物筛选服务 |
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