生命科学学院

发表论文：

[1]Wu L (#), Chen F (#), Chang X, Li L, Yin X, Li C, Wang F, Li C, Xu Q, Zhuang H (*), Gu N (*), Hua ZC (*). Combined Cellular Thermometry Reveals That Salmonella typhimurium Warms Macrophages by Inducing a Pyroptosis-like Phenotype.J Am Chem Soc. 2022 Oct 26;144(42):19396-19409. (*通讯作者，IF=16.383)

[2]Lin Y, Peng N, Li J, Zhuang H (*), Hua ZC (*). Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase. Mol Cancer. 2013 Jun 8; 12:54. (*通讯作者，IF=41.444)

[3]Zhuang H, Wang X, Zha D, Gan Z, Cai F, Du P, Yang Y, Yang B, Zhang X, Yao C, Zhou Y, Jiang C, Guan S, Zhang X, Zhang J, Jiang W, Hu Q, Hua ZC (*). FADD is a key regulator of lipid metabolism. EMBO Mol Med. 2016 Aug 1;8(8):895-918. (第一作者，IF=14.260)

[4]Jiang W (#), Cai F (#), Xu H, Lu Y, Chen J, Liu J, Cao N, Zhang X, Chen X, Huang Qilai, Zhuang H(*), Hua ZC (*). Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner. Protein Cell. 2020 Nov;11(11):825-845. (*通讯作者，IF=21.1)

[5]Jiang W (#), Jin G (#), Cai F, Chen X, Cao N, Zhang X, Liu J, Chen F, Wang F, Dong W, Zhuang H(*), Hua ZC (*). Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response. Exp Mol Med. 2019 Feb 21;51(2):1-20. (*通讯作者，IF=12.153)

[6]Cai F, Li D, Xie Y, Wang X, Ma H, Xu H, Cheng J (*), Zhuang H (*), Hua ZC (*). Sulfide:quinone oxidoreductase alleviates ferroptosis in acute kidney injury via ameliorating mitochondrial dysfunction of renal tubular epithelial cells. Redox Biol. 2023 Nov 29;69:102973.(*通讯作者，IF=11.4)

[7]Fu S (#), Cao Z (#), Huang B (#), Yin T, Huang C, Bi Z, Yao Y, Chang X, Zhuang H (*), Hua ZC (*). Tannic acid assisted anti-TNF-α nanobody assembly modulating the epithelial barrier dysregulation of allergic rhinitis. Nano Research. 2023 Mar 08. Available online.https://doi.org/10.1007/s12274-023-5646-6. (*通讯作者，IF=10.269)

[8]Bi Z (#), Chen J (#), Chang X, Li D, Yao Y, Cai F, Xu H, Cheng J, Hua ZC (*), Zhuang H (*). ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis. Frontiers of Medicine. 2023. Accepted. (*通讯作者，IF=9.927)

[9]Cai F, Xu H, Cao N, Zhang X, Liu J, Lu Y, Chen J, Yang Y, Cheng J (*), Hua ZC (*), Zhuang H (*). ADT-OH, a hydrogen sulfide-releasing donor, induces apoptosis and inhibits the development of melanoma in vivo by upregulating FADD. Cell Death Dis. 2020 Jan 16;11(1):33. (*通讯作者，IF=9.685)

[10]Gao M, Yang C, Wu C, Chen Y, Zhuang H (*), Wang J (*), Cao Z (*). Hydrogel-metal-organic-framework hybrids mediated efficient oral delivery of siRNA for the treatment of ulcerative colitis. J Nanobiotechnology. 2022 Sep 5;20(1):404. (*通讯作者，IF=9.429)

[11]Xu H, Cai F, Li P, Wang X, Yao Y, Chang X, Bi Z, Sun H, Zhuang H (*), Hua ZC (*).Characterization and Analysis of the Temporal and Spatial Dynamic of Several Enteritis Modeling Methodologies.Front Immunol. 2021 Dec 22;12:727664. (*通讯作者，IF=8.786)

[12]Xu H, Li P, Wang X, Zhuang H (*), Hua ZC (*).Emerging roles of hnRNP A2B1 in cancer and inflammation.Int J Biol Macromol. 2022 Nov 30;221:1077-1092. (*通讯作者，IF=8.025)

[13]Cai FF, Xu HR, Yu SH, Li P, Lu YY, Chen J, Bi ZQ, Sun HS, Cheng J,Zhuang HQ (*), Hua ZC (*).ADT-OH inhibits malignant melanoma metastasis in mice via suppressing CSE/CBS and FAK/Paxillin signaling pathway.Acta Pharmacol Sin. 2022 Jul;43(7):1829-1842. (*通讯作者，IF=7.169)

[14]Yao C (#),Zhuang H (#), Du P, Cheng W, Yang B, Guan S, Hu Y, Zhu D, Christine M, Shi L, Hua ZC (*). Role of FADD Phosphorylation in Regulating Glucose Homeostasis: from Proteomic Discovery to Physiological Validation. Mol Cell Proteomics. 2013 Oct;12(10):2689-2700. (#共同第一作者，IF=7.381)

[15]Chen J (#), Wei D (#), Zhuang H(#), Qiao Y, Tang B, Zhang X, Wei J, Fang S, Chen G, Du P, Huang X, Jiang W, Hu Q, Hua ZC (*). Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications. Mol Cell Proteomics. 2011 Jun;10(6):M111.009399. (#共同第一作者，IF=7.381)

[16]Yao C (#), Zhuang H (#), Cheng W, Lin Y, Du P, Yang B, Huang X, Chen S, Hu Q, Hua ZC (*). FADD phosphorylation impaired islet morphology and function. J Cell Physiol. 2015 Jul;230(7):1448-56. (#共同第一作者，IF=6.513)

[17]Bi Z, Cui E, Yao Y, Chang X, Wang X, Zhang Y, Xu GX, Zhuang H (*), Hua ZC (*).Recombinant Bifidobacterium longum Carrying Endostatin Protein Alleviates Dextran Sodium Sulfate-Induced Colitis and Colon Cancer in Rats.Front Microbiol. 2022 Jun 30;13:927277. (*通讯作者，IF=6.064)

[18]Zhuang H, Jiang W, Cheng W, Qian K, Dong W, Cao L, Huang Q, Li S, Dou F, Chiu JF, Fang XX, Lu M, Hua ZC (*). Down-regulation of HSP27 sensitizes TRAIL-resistant tumor cell to TRAIL-induced apoptosis.Lung Cancer. 2010 Apr;68(1):27-38. (第一作者，IF=6.081)

[19]Cao N (#), Lu Y (#), Liu J (#), Cai F, Xu H, Chen J, Zhang X, Hua ZC (*), Zhuang H (*). Metformin Synergistically Enhanced the Antitumor Activity of Celecoxib in Human Non-Small Cell Lung Cancer Cells. Front Pharmacol. 2020 Jul 22;11:1094. (*通讯作者，IF=5.988)

[20]Cai F, Xu H, Zha D, Wang X, Li P, Yu S, Yao Y, Chang X, Chen J, Lu Y, Hua ZC (*), Zhuang H (*).AK2 Promotes the Migration and Invasion of Lung Adenocarcinoma by Activating TGF-β/Smad Pathway In vitro and In vivo. Front Pharmacol. 2021 Sep 22;12:714365. (*通讯作者，IF=5.988)

[21]Zhuang H, Jiang W, Zhang X, Qiu F, Gan Z, Cheng W, Zhang J, Guan S, Tang B, Huang Q, Wu X, Huang X, Jiang W, Hu Q, Lu M, Hua ZC (*). Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions. J Mol Med (Berl). 2013 Feb;91(2):219-35. (第一作者，IF=5.606)

[22]Zhang X (#), Chen J (#), Cheng C (#), Li P, Cai F, Xu H, Lu Y, Cao N, Liu J, Wang J (*), Hua ZC (*), Zhuang H (*). Aspirin potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer by targeting GRP78 activity. Ther Adv Med Oncol. 2020 Sep 17;12:1758835920947976. (*通讯作者，IF=5.485)

[23]Zhuang H, Gan Z, Jiang W, Zhang X, Hua ZC (*). Comparative proteomics analysis reveals roles for FADD in the regulation of energy metabolism and proteolysis pathway in mouse embryonic fibroblast. Proteomics. 2013 Aug;13(16):2398-413. (第一作者，IF= 5.393)

[24]Lin Y (#), Cai F (#), Wang X, Yang Y, Ren Y, Yao C, Yin X, Zhuang H (*), Hua Z (*).FADD phosphorylation contributes to development of renal fibrosis by accelerating epithelial-mesenchymal transition. Cell Cycle. 2022 Oct 24:1-16. (*通讯作者，IF=5.173)

[25]Chen M, Wang X, Zha D, Cai F, Zhang W, He Y, Huang Q, Zhuang H (*), Hua ZC (*). Apigenin potentiates TRAIL therapy of non-small cell lung cancer via upregulating DR4/DR5 expression in a p53-dependent manner. Sci Rep. 2016 Oct 18;6:35468. (*通讯作者，IF=4.996)

[26]Lin Y (#), Peng N (#), Zhuang H (#), Zhang D, Wang Y (*), Hua ZC (*). Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor. BMC Cancer. 2014 Aug 30; 14:639. (#共同第一作者，IF=4.638)

[27]Lin Y, Liu J, Chen J, Yao C, Yang Y, Wang J, Zhuang H (*), Hua ZC (*). FADD phosphorylation modulates blood glucose levels by decreasing the expression of insulin-degrading enzyme. Mol Cells. 2020 Apr 30;43(4):373-383. (*通讯作者，IF=4.250)

[28]Zhuang H, Gan Z, Jiang W, Zhang X, Hua ZC (*). Functional specific roles of FADD: comparative proteomic analyses from knockout cell lines. Mol Biosyst. 2013 Aug 2; 9(8):2063-78. (第一作者，IF=4.212)

[29]Li J, Lin Y, Zhuang H (*), Hua ZC (*). Expression, Purification and Biological Characterization of The Amino-Terminal Fragment of Urokinase in Pichia pastoris. J Microbiol Biotechnol. 2013 Sep 28;23(9):1197-205. (*通讯作者，IF= 3.277)

[30]Lin Y, Yang X, Lu M, Zheng W, Zhang J, Zhuang H (*), Hua ZC (*). Herbal compound triptolide synergistically enhanced antitumor activity of vasostatin120-180. Anti-Cancer Drugs. 2013 Oct;24(9):945-57. (*通讯作者，IF= 2.389)

[31]Lin Y, Yang X, Lu M, Zhuang H (*), Hua ZC (*). Expression, purification and biological characterization of human vasostatin120–180 in Pichia pastoris. Protein Expr Purif. 2013 Oct 1;92(2):141-147. (*通讯作者，IF= 2.025)

专利申请及授权：

[1]华子春，庄红芹。一种调控热休克蛋白70表达、数量及活性的方法及其应用，2018.02.02-2032.08.16, 中国, ZL201210293661.9。 (已授权专利)

[2]Zichun Hua, Jianxiang Chen, Dongping Wei, Hongqin Zhuang, Method of Anaerobic Tissue-targeted Gene Expression Initiated by Alcohol Dehydrogenase Promoter and the Application Thereof, 2017.07.18-2034.10.14, 美国, US 9,708,617 B2。(已授权专利)

[3]ZICHUN HUA, HONGQIN ZHUANG. METHOD FOR REGULATING LIPOLYSIS AND FATTY ACID OXIDATIVE METABOLISM, 2022.05.10-2038.12.19, 美国, US 11,324,796 B2。(已授权专利)

[4]华子春，庄红芹。一种调节脂解和脂肪酸氧化代谢的方法。2016，中国，专利申请号：201610453256.7。

[5]Zichun Hua, Hongqin Zhuang. Method for Regulating Lipolysis and Fatty Acid Oxidative Metabolism, 2019.1.8, 日本, 2018-566846。

[6]Zichun Hua, Hongqin Zhuang. Method for Regulating Lipolysis and Fatty Acid Oxidative Metabolism, 2019.1.14, 欧洲, 16906140.5。

[7]华子春，庄红芹，蔡芳芳。一种使用硫化氢缓释供体ADT-OH抑制黑色素瘤转移的方法及其应用。2021，中国，专利申请号：2021115114999。

[8]华子春，庄红芹，毕志倩。一种携带内皮抑素蛋白的重组长双歧杆菌在制备治疗小鼠结肠炎和结直肠癌的药物中的应用。2022，中国，专利申请号：2022106975230。

科研奖励：

[1]华子春，徐根兴，高国全，庄红芹，房学迅，侯亚义。胞外基质降解产物的抗肿瘤作用、蛋白质工程改造及其应用。江苏省科学技术一等奖，2017。

[2]华子春，徐根兴，高国全，庄红芹，房学迅，侯亚义。胞外基质降解产物的抗肿瘤作用、蛋白质工程改造及其应用。江苏省第四届医药科技进步二等奖，2017。

主持科研项目：

1.国家自然科学基金面上项目，核不均一核糖核蛋白hnRNP A2/B1的新功能：胰岛素抵抗调控及其分子机制研究（82370816），2023.1-2026.12，50万元，在研，主持。

2.国家自然科学基金面上项目，经典死亡蛋白FADD对脂代谢的调控及其分子机制研究（81570790），2016.1-2019.12, 69万元，已结题，主持。

3.国家自然科学基金面上项目，死亡蛋白FADD的新功能：上皮-间质转化（EMT）调控及其分子机制研究（81773099），2018.1-2021.12，71万元，已结题，主持。

4.江苏省自然科学基金面上项目，经典死亡蛋白FADD 对脂代谢的调控及其分子机制研究（BK20151457），2015.7-2018.6,10万元，已结题，主持。

5.国家重点研发计划精准医学研究，口腔癌演进过程的分子分类体系和精准诊疗标志物研究（No. 2016YFC0902700, Precision Medicine），2016.6-2018.12, 8万元，已结题，南京大学子课题负责人。

6.国家自然科学基金青年基金项目，uPAR调控肿瘤转移新途径的分子机制研究（31200572），2012.1-2015.12, 25万元，已结题，主持。

7.江苏省自然科学基金项目，BK2011228，HSP27、HSP70 对TRAIL 介导的细胞凋亡通路的精细调控及其在肺癌治疗中的应用，2012/01-2014/12，8万元，已结题，主持。

8.常州市科技局国际科技合作计划项目，CZ20110028，江苏-维州生物医药产业创新联盟常州总部，2011/04-2013/04，20万元，已结题，主持。

9.国家高技术研究发展计划课题，2012AA020304，药靶发现与药物分子设计技术（多肽分子药靶发现与药物设计技术），2012.07-2017.06，46.2万元，已结题，参加（南京大学子课题负责人）。

10.中国博士后科学基金面上资助，20090461101，热休克蛋白HSP27、HSP70调控肺癌细胞对TRAIL诱导的细胞凋亡敏感性及其分子机制研究，2010.01-2010.12，3万元，已结题，主持。

11.干细胞重大研究计划，2012CB967004，肿瘤干细胞的动态演进及干预研究（肿瘤干细胞的特异性干预靶点研究），2012.01-2016.12，180万元，已结题，参加。