生命科学学院

代表性论文：

Selected publications:

1. Y.X. Shu, N.F. Yang, N. Cheng , Z.Y. Zou , W.L. Zhang , Y.C. Bei, Q. Shi, M.H. Qin, W.G. Zhu*, P.P. Shen*. Intervening pyruvate carboxylase stunts tumor growth by strengthening anti-tumor actions of tumor-associated macrophages. Signal Transduct Target Ther. 2022, 7:34.

2. N.F. Yang, Y.X. Wang, Q. Tian, Q.P. Wang, Y. Lu, L.C. Sun, S.J. Wang, Y.C. Bei, J.G. Ji, H. Zhou, W. Yang, P.J. Yao, W.Y. Zhu, L.Y. Sun, Z.F. Huang, X.K. Li, P.P. Shen*. Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions. Cell Death Differ. 2023, 30:766-778.

3. Z.Y. Niu, Q. Shi, W.L. Zhang, B. Chen, Q.S. Wang, X.Y. Zhao, J.J. Chen , Y.X. Shu, N. Cheng, X.J. Feng, J.G. Ji, P.P. Shen*. Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs.Nat Commun.2017, 8:766.

4. Y.C. Bei, N. Cheng, T. Chen, Y.X. Shu, Y. Yang , N.F. Yang, X.Y. Zhou, B.R. Liu, J. Wei, Q. Liu, W. Zheng , W.L. Zhang , H.F. Su, W.G. Zhu, J.G. Ji, P.P. Shen*. CDK5 Inhibition Abrogates TNBC Stem-cell Property and Enhances Anti-PD-1 Therapy. Adv Sci.2020, 7:2001417.

5. W.L. Zhang, Q. Zhang, N.F. Yang, Q. Shi, H.F. Su, T.S. Lin, Z.L. He, W.X. Wang, H.Q. Guo*, P.P. Shen*. Crosstalk between IL-15Rα+ tumor-associated macrophages and breast cancer cells reduces CD8+ T cell recruitment. Cancer Commun (Lond). 2022, 42(6):536-557.

6. N.F. Yang, Q. Tang, W.T. Qin, Z.Y. Li, D.D. Wang, W.J. Zhang, X. Cao, Y. Lu, X.Y. Ge, H.B. Sun*, P.P. Shen*. Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization. EBioMedicine.2019, 45:473-486.

7. P. Liu, C. Li, R.X. Zhang , Q. Tang, J. Wei, Y. Lu, P.P. Shen*. An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy. Biosens Bioelectron.2019, 126: 543-550.

8. J.L. Li, J.Q. Fan, Y. Gao, S.D. Huang, D. Huang, J.C. Li, X.Y. Wang, Hélder A. Santos,* P.P. Shen*, B. Xia*. Porous Silicon Nanocarriers Boost the Immunomodulation of Mitochondria Targeted Bovine Serum Albumins on Macrophage Polarization. ACS Nano.2023, 17: 1036-1053.

9. S.M. Zuo, L.C. Sun, Y.X. Wang, B. Chen, J.Y. Wang, X.Y. Ge, Y. Lu, N.F. Yang *, P.P. Shen*. Establishment of a novel mesenchymal stem cell-based regimen for chronic myeloid leukemia differentiation therapy. Cell Death Dis.2021, 12: 208.

10. W.L. Zhang, L. Liu, H.F. Su, Q. Liu, J. Shen, H.R. Dai, W. Zheng, Y. Lu, W.J. Zhang, Y.C. Bei, P.P. Shen*. Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix. Br J Cancer.2019, 121(10):837-845.

授权专利：  

1.     沈萍萍，孙璐琛，杨南飞，郑薇. 一种提高间充质干细胞促进急性髓系白血病细胞分化能力的诱导方法. 专利申请日: 2020/04/10，专利号：ZL202010282961.1，授权公告日：2023/2/3，授权公告号：CN111454896B

2.     沈萍萍，束雨新，贝云成，杨南飞.一种增强抗肿瘤免疫功能的双效组合纳米体系构建。专利申请日：2020/01/10，专利号：ZL202010029582.1，授权公告日：2022/11/29，授权公告号：CN 113116923B

3.     沈萍萍，章文龙，唐嘉荩，黄亚红. 一种高效的小鼠骨髓来源巨噬细胞的转染方法及其应用。专利申请日：2018/10/17，专利号：ZL201811233196.3，授权公告日：2022/11/11，授权公告号：CN 111057719B

4.     沈萍萍，贝云成，刘培，一种用于乳腺癌免疫治疗的联合用药物组合及其应用。申请日期：2018/05/09；专利号：ZL 201810453420.3，授权公告日：2022/06/07，授权公告号：CN 110464845B

5.     沈萍萍，牛志远，一种具有抗肿瘤功能的免疫细胞及其应用。申请日期：2016/12 /02，专利号：ZL 201611095758.3，授权公告日：2020/03/17

6.     沈萍萍，姚永芳，陈兵，黄亚红，一种间充质干细胞在制备治疗M5型白血病药物中的应用。ZL201610208206.2，授权公告日：2019/09/20

7.     沈萍萍，丁森，卢彦，一种基于酶联免疫分析的HPV核酸检测试剂盒及其应用。ZL 201410298037.7，2016/02/23

8.     沈萍萍，丰秀静，徐加发，杨威威，一种白杨素噻唑衍生物及其制备方法和应用。 ZL 201310169151.5，2015/02/26

9.     沈萍萍，蔡梅红，一种杂合肽囊素佐剂及其制备方法和应用。  

ZL 201210295586.X，2014/12/10

10.  沈萍萍，蔡梅红，一种重组b干扰素的制备方法及其应用。

ZL 201110044022.4，2013/03/13/

11.  沈萍萍，卢彦，徐加法，香豆素标记雷公藤内酯醇及其制备方法和应用。

ZL 200910035979.5，2012/07/25

12.  华子春，沈萍萍，潘晓，一种小分子化合物的酵母三杂交检测系统及其在藻毒素检测中的应用。ZL 200710132796.6，2010/12/01