龚岚

三、主要科研工作与成绩

科研项目：

（1）国家自然科学基金面上项目（2021.01~2024.12）《五羟色胺及去甲肾上腺素再摄取抑制剂抑制干眼病发展的机制研究》项目批准号82070924，资助资金57万（项目负责人）

（2）国家自然科学基金面上项目（2017.01~2020.12）《五羟色胺再摄取抑制剂和干眼病发病通路的机制研究》项目批准号81670819，资助资金51万（项目负责人）

（3）国家自然科学基金面上项目（2009.01~2011.12）《针刺对兔泪液蛋白成分改变的实验研究》项目批准号30873287，资助资金31万（项目负责人）

（4）上海市2022年度“科技创新行动计划”医学创新研究专项项目（2022.07-2025.06）《基于非侵入性鼻外神经刺激法的干眼非药物治疗策略的临床评价》项目批准号22Y11910300，资助资金30万（项目负责人）

（5）上海市优秀技术带头人计划（2018.04~2021.03）《温敏性医用水凝胶眼科植入系统的临床开发》项目批准号18XD1424500，资助资金40万（项目负责人）

（6）上海市科委科技支撑项目（2018.04~2021.03）《基于温敏性几丁糖水凝胶的个体化配适生物绷带镜研发》项目批准号18441902500，资助资金35万（项目负责人）

（7）上海市科学技术委员会生物医药处面上项目（2017-10.01~2020-9-30）《研究优化强脉冲光技术在睑板腺功能障碍治疗》项目批准号17411961800，资助资金20万（项目负责人）

（8）上海市科学技术委员会生物医药处面上项目（2012.10.01~2015.09.30）《OCT在针刺治疗干眼症中的应用》项目编号12401907300，资助金额10万（项目负责人）

（9）上海市科学技术委员会生物医药处面上项目（2014.07.01~2017.09.30）《中医熏洗法联合常规治疗方案对睑板腺功能障碍的疗效分析》项目编号14401931400，资助金额10万（项目负责人）

近五年主要论文：

Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L, Le Q. WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway. Cell Prolif. 2023 Mar 27:e13460.

Zhao H, Lin T, Yang Y, Feng C, Wang W, Gong L. The effect of short-term air pollutants exposure on outpatient admission for blepharitis in Shanghai, China: a hospital-based study. Environ Sci Pollut Res Int. 2023 Apr;30(16):47655-47669.

Liu W, Lin T, Gong L. Meibomian gland dysfunction patients benefit in ocular parameters and tear chemokines after thermal pulsation treatment. Int J Med Sci. 2023 Jan 1;20(1):11-22.

Yin Y, Gong L, Lu Y. The Approach of Intense Pulsed Light Treatment in Patients with Different Severities of Meibomian Gland Dysfunction. Curr Eye Res. 2023 Mar;48(3):231-237

Zhao S, Wan X, Dai Y, Gong L, Le Q. WNT16B enhances the proliferation and self-renewal of limbal epithelial cells via CXCR4/MEK/ERK signaling. Stem Cell Reports. 2022 Apr 12;17(4):864-878

Wang W, Gong L, Wang Y. Anatomic characteristics of primary acquired nasolacrimal duct obstruction: a comparative computed tomography study. Quant Imaging Med Surg. 2022 Nov;12(11):5068-5079.

Lin T, Feng C, Bi Y, Lu P, Wu M, Qu J, Gong L, Sun X. Lidocaine Hydrochloride Gel for Ocular Surface Anesthesia: Pharmacokinetic Evaluation and Randomized Placebo-Controlled Trial in China. J Ocul Pharmacol Ther. 2022 Oct;38(8):567-575.

Zhao H, Chen Y, Shen P, Gong L. Prognostic value and immune characteristics of RUNX gene family in human cancers: a pan-cancer analysis. Aging (Albany NY). 2022 May 6;14(9):4014-4035.

Liu N, He A, Wu D, Gong L, Song N. Skin redraping for correction of lower eyelid epiblepharon combined with medial epicanthal fold: a retrospective analysis of 286 Asian children. Eye (Lond). 2022 Apr;36(4):844-849

Zhao H, Chen Y, Shen P, Gong L. Identification of Immune Cell Infiltration Landscape and Their Prognostic Significance in Uveal Melanoma. Front Cell Dev Biol. 2021 Aug 26;9:713569.

Liu W, Gong L. Anti-demodectic effects of okra eyelid patch in Demodex blepharitis compared with tea tree oil. Exp Ther Med. 2021 Apr;21(4):338.

Zhao S, Song N, Gong L. Changes of Dry Eye Related Markers and Tear Inflammatory Cytokines After Upper Blepharoplasty. Front Med (Lausanne). 2021 Dec 9;8:763611.

Lin T, Wang W, Lu Y, Gong L. Treatment of Dry Eye With Intracanalicular Injection of Hydroxybutyl Chitosan: A Prospective Randomized Clinical Trial. Front Med (Lausanne). 2021 Nov 18;8:769448.

Zhao H, Chen Y, Shen P, Gong L. Construction and validation of a novel prognostic signature for uveal melanoma based on five metabolism-related genes. Math Biosci Eng. 2021 Sep 15;18(6):8045-8063

Lu Y, Yin Y, Gong L. Meibomian gland dysfunction model induced with complete Freund's adjuvant in C57BL/6 mice. Int J Ophthalmol. 2020 Nov 18;13(11):1705-1712.

Zhang LM, Lu Y, Gong L. Pterygium Is Related to Short Axial Length. Cornea. 2020 Feb;39(2):140-145.

Zhang X, Yin Y, Yue L, Gong L. Selective Serotonin Reuptake Inhibitors Aggravate Depression-Associated Dry Eye Via Activating the NF-κB Pathway. Invest Ophthalmol Vis Sci. 2019 Jan 2;60(1):407-419

Lin T, Zhang X, Lu Y, Gong L. TGFBIp mediates lymphatic sprouting in corneal lymphangiogenesis. J Cell Mol Med. 2019 Nov;23(11):7602-7616

Lin T, Zhang X, Lu Y, Gong L. Identification of Circular RNA Related to Inflammation-Induced Lymphangiogenesis by Microarray Analysis. DNA Cell Biol. 2019 Aug;38(8):887-894.

Yin Y, Gong L. The quantitative measuring method of meibomian gland vagueness and diagnostic efficacy of meibomian gland index combination. Acta Ophthalmol. 2019 May;97(3):e403-e409.

Chen M, Dai J, Gong L. Changes in Retinal Vasculature and Thickness after Small Incision Lenticule Extraction with Optical Coherence Tomography Angiography. J Ophthalmol. 2019 May 20;2019:3693140

Zhang X, Song N, Gong L. Therapeutic Effect of Intense Pulsed Light on Ocular Demodicosis. Curr Eye Res. 2019 Mar;44(3):250-256.

Lin T , Lu Y , Zhang X , Gong L , Wei C . Treatment of dry eye by intracanalicular injection of a thermosensitive chitosan-based hydrogel: evaluation of biosafety and availability. Biomater Sci. 2018 Nov 20;6(12):3160-3169

Yin Y, Liu N, Gong L, Song N. Changes in the Meibomian Gland After Exposure to Intense Pulsed Light in Meibomian Gland Dysfunction (MGD) Patients. Curr Eye Res. 2018 Mar;43(3):308-313.

Zhang J, Duan J, Gong L. Super pulse CO2 laser therapy for benign eyelid tumors. J Cosmet Dermatol. 2018 Apr;17(2):171-175

专著：

《眼耳鼻喉科常见疾病的食疗保健》  2015年9月   副主编

《泪道病图谱》 2020年9月  副主译

专利：

一种ZD6474在翼状胬肉术后抗复发的治疗药物制备中的应用 申请号：2021107280906 国家发明专利

一种原位成胶个体化配适的角膜绷带镜 申请号：2021106385991 国家发明专利

一种对睑板腺腺体清晰度评估的图像检测方法 授权号 CN 111528789 B 国家发明专利

一种应用于泪道注射的温敏性几丁糖专用水凝胶注射器 申请号：2017113613676 国家发明专利