多功能磁性介孔Fe3O4@MSN@PPy

本文采用水热合成法制备了超顺磁性氧化铁(Fe 3 O 4 )纳米球，并通过介孔二氧化硅纳米球(MSN)层包覆Fe 3 O 4 @MSN@PPy-HA制备了Fe 3 O 4 @MSN@PPy-HA复合微球。光热转换材料聚吡咯（PPy）和肿瘤靶向配体透明质酸（HA）。将化疗药物阿霉素（DOX）添加到上述材料中，制备肿瘤靶向的Fe 3 O 4 @MSN@PPy-HA@DOX微球。复合纳米球具有优异的载药能力、可控的药物释放光热转换性能好，生物安全性好，可用于肿瘤的治疗。在近红外激光照射下，Fe 3 O 4 @MSN@PPy-HA纳米球的光热转换效率可达24.61%，实现了肿瘤部位的热消融。纳米球中含有的二价铁离子（Fe 2+ ）可与肿瘤细胞内的过氧化氢（H 2 O 2 ）发生芬顿反应，形成细胞毒性羟自由基（·OH），从而实现肿瘤化学动力学治疗（CDT） 。该研究证实微球具有良好的肿瘤抑制作用，为多功能复合纳米材料的设计提供了新的思路。

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In this paper, superparamagnetic ferric oxide (Fe3O4) nanospheres were prepared by hydrothermal synthesis and Fe3O4@MSN@PPy-HA composite microspheres were prepared by coating the Fe3O4 with mesoporous silica nanospheres (MSN) layer, photothermal conversion materials polypyrrole (PPy) and tumor-targeting ligand hyaluronic acid (HA). The chemotherapy drug doxorubicin (DOX) was added to the above materials to prepare the tumor-targeting Fe3O4@MSN@PPy-HA@DOX microspheres. The composite nanospheres have excellent drug loading ability, controlled drug release ability, photothermal conversion performance, and good biological safety, which can be used in the treatment of tumors. Under the irradiation of the NIR laser, the photothermal conversion efficiency of Fe3O4@MSN@PPy-HA nanospheres can reach 24.61 %, realizing the thermal ablation of tumor sites. The bivalent iron ion (Fe2+) contained in the nanospheres can have a Fenton reaction with the hydrogen peroxide (H2O2) in tumor cells to form cytotoxic hydroxyl radical (·OH), thus achieving the tumor chemodynamic therapy (CDT). This study confirmed that the microspheres have a good tumor inhibition effect and provided a new idea for the design of multifunctional composite nanomaterials.