交通相关空气污染与阻塞性睡眠呼吸暂停之间的关联：系统评价。,Sleep Medicine Reviews

最近的证据表明，空气污染暴露可能是阻塞性睡眠呼吸暂停 (OSA) 的一个危险因素，但是，目前的证据相互矛盾。本系统评价旨在确定一般人群中空气污染与 OSA 之间的关联，并检查季节性、温度和湿度对潜在影响的改变。通过系统地搜索 PubMed、Embase 和 Scopus 数据库发现的 905 篇文章中，有 5 篇全文文章被纳入审查。纳入的研究仅限于在中等至高收入国家进行的成人 OSA。结果突出了 OSA 诊断标准和用于评估空气污染暴露的方法的异质性。有一些证据支持空气污染暴露与 OSA 之间的关系。然而，与OSA 相关的2.5和 PM 10 ) 和一氧化氮 (NO 2 ) 因季节、温度和国家而异。研究中污染物的这种可变性需要使用时间序列分析和多次随访来加强这种关系的证据，然后再考虑其影响，从而进行更稳健的研究设计。

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Recent evidence suggests that air pollution exposure may be a contributing risk factor for obstructive sleep apnea (OSA), however, current evidence is conflicting. This systematic review aims to determine the association between air pollution and OSA in the general population, and examine for potential effect modification by seasonality, temperature and humidity. Five full-text articles were included in the review out of 905 articles found by systematically searching PubMed, Embase and Scopus databases. The included studies were limited to OSA in adults that were conducted in middle to high-income countries. The results highlight heterogeneity in the diagnostic criteria for OSA and method used to assess air pollution exposure. There is some evidence to support a relationship between air pollution exposure and OSA. However, the duration of exposure to different air pollutants including particulate matter (PM2.5 and PM10) and nitric oxides (NO2) in relation to OSA varied across different seasons, temperatures, and countries. This variability of the pollutants across studies warrants a more robust study design using time-series analysis with multiple follow-ups to strengthen the evidence for this relationship before considering its implications.