| The influence of interferon on healthy and diseased skin,Cytokine | 您所在的位置：网站首页 › kahlenberg反应中文 › The influence of interferon on healthy and diseased skin,Cytokine |
The influence of interferon on healthy and diseased skin,Cytokine
|
Type I interferons (IFNs) are an immunomodulatory class of cytokines that serve to protect against viral and bacterial infection. In addition, mounting evidence suggests IFNs, particularly type I but also IFNγ, are important to the pathogenesis of autoimmune and inflammatory skin diseases, such as cutaneous lupus erythematosus (CLE). Understanding the role of IFNs is relevant to anti-viral responses in the skin, skin biology, and therapeutics for these IFN-related conditions. Type I IFNs (α and β) are produced by recruited inflammatory cells and by the epidermis itself (IFNκ) and have important roles in autoimmune and inflammatory skin disease. Here, we review the current literature utilizing a PubMed database search using terms [interferon/IFN/type I IFN AND lupus/ cutaneous lupus/CLE/dermatomyositis/Sjogrens/psoriasis/lichen planus/morphea/alopecia areata/vitiligo] with a focus on the role of IFNs in basic keratinocyte biology and their implications in the cutaneous autoimmune and inflammatory diseases: cutaneous lupus erythematosus, dermatomyositis, Sjogren's syndrome, psoriasis, lichen planus, alopecia areata and vitiligo. We provide information about genes and proteins induced by IFNs and how downstream mechanisms relate to clinical disease.
中文翻译：
I 型干扰素 (IFN) 是一类免疫调节细胞因子，可防止病毒和细菌感染。此外，越来越多的证据表明 IFN，尤其是 I 型和 IFNγ，对自身免疫性和炎症性皮肤病（例如皮肤红斑狼疮 (CLE)）的发病机制很重要。了解 IFN 的作用与皮肤中的抗病毒反应、皮肤生物学和这些 IFN 相关病症的治疗相关。I 型 IFN（α 和 β）由募集的炎症细胞和表皮本身 (IFNκ) 产生，在自身免疫性和炎症性皮肤病中具有重要作用。这里，我们利用 PubMed 数据库搜索使用术语 [干扰素/干扰素/I 型干扰素和狼疮/皮肤狼疮/CLE/皮肌炎/干燥症/牛皮癣/扁平苔藓/硬斑病/斑秃/白癜风] 来回顾当前的文献，重点关注作用IFN 在基本角质形成细胞生物学中的作用及其在皮肤自身免疫和炎症性疾病中的意义：皮肤红斑狼疮、皮肌炎、干燥综合征、牛皮癣、扁平苔藓、斑秃和白斑。我们提供有关 IFN 诱导的基因和蛋白质的信息，以及下游机制与临床疾病的关系。扁平苔藓、斑秃和白斑。我们提供有关 IFN 诱导的基因和蛋白质的信息，以及下游机制与临床疾病的关系。扁平苔藓、斑秃和白斑。我们提供有关 IFN 诱导的基因和蛋白质的信息，以及下游机制与临床疾病的关系。 |
【本文地址】
公司简介
联系我们