钙网蛋白作为癌症的标志物和治疗靶点,Clinical and Experimental Medicine

钙网蛋白 (CRT) 是在内质网 (ER) 中发现的一种多功能蛋白质。此外，CRT参与肿瘤的形成和发展，促进肿瘤细胞的增殖和迁移。当人体发生恶性肿瘤时，死于免疫原性细胞死亡（ICD）的癌细胞将CRT暴露在其表面，转移到细胞表面的CRT代表“吃我”信号，促进树突状细胞吞噬肿瘤细胞，从而增加肿瘤对抗癌免疫治疗的敏感性。CRT在肿瘤组织中的表达高于正常组织，并且与许多恶性肿瘤的疾病进展相关。因此，CRT 产生功能失调会促进肿瘤发生，因为它不仅扰乱健康细胞的平衡，而且扰乱人体的免疫监视。CRT 可能是癌症的诊断标志物和治疗靶点，本综述对此进行了广泛讨论。

"点击查看英文标题和摘要"

Calreticulin (CRT) is a multifunctional protein found within the endoplasmic reticulum (ER). In addition, CRT participates in the formation and development of tumors and promotes the proliferation and migration of tumor cells. When a malignant tumor occurs in the human body, cancer cells that die from immunogenic cell death (ICD) expose CRT on their surface, and CRT that is transferred to the cell surface represents an "eat me" signal, which promotes dendritic cells to phagocytose the tumor cells, thereby increasing the sensitivity of tumors to anticancer immunotherapy. Expression of CRT in tumor tissues is higher than in normal tissues and is associated with disease progression in many malignant tumors. Thus, the dysfunctional production of CRT can promote tumorigenesis because it disturbs not only the balance of healthy cells but also the body's immune surveillance. CRT may be a diagnostic marker and a therapeutic target for cancer, which is discussed extensively in this review.