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参考文献：

[1] Shi, Donghua, et al. "Chimeric antigen receptor-glypican-3 T-cell therapy for advanced hepatocellular carcinoma: Results of phase I Trials." Clinical Cancer Research 26.15 (2020): 3979-3989.

[2] Feng, Mingqian, et al. "Recombinant soluble glypican 3 protein inhibits the growth of hepatocellular carcinoma in vitro." International journal of cancer. journal international du cancer 128.9 (2011): 2246.

[3] Zong, Jingjing, Zhe Fan, and Yewei Zhang. "Serum Tumor Markers for Early Diagnosis of Primary Hepatocellular Carcinoma. "Journal of Hepatocellular Carcinoma 7 (2020): 413.

[4] Ho, Mitchell, and Heungnam Kim. "Glypican-3: a new target for cancer immunotherapy. "European journal of cancer 47.3 (2011): 333- 338.

[5] Nishida, Takahiro, and Hiroaki Kataoka. "Glypican 3-targeted therapy in hepatocellular carcinoma. "Cancers 11.9 (2019): 1339.

[6] Montalbano, Mauro, et al. "Role of Glypican-3 in the growth, migration and invasion of primary hepatocytes isolated from patients with hepatocellular carcinoma." Cellular Oncology 41.2 (2018): 169-184.

[7] Filmus, Jorge, and Mariana Capurro. "Glypican-3: a marker and a therapeutic target in hepatocellular carcinoma. "The FEBS journal 280.10 (2013): 2471-2476.

[8] Ou-Yang, Robin J., et al. "Expression of glypican 3 in placental site trophoblastic tumor." Diagnostic pathology 5.1 (2010): 1-6.

[9] Pan, Zhijian, et al. "Overexpression of GPC3 inhibits hepatocellular carcinoma cell proliferation and invasion through induction Molecular medicine reports 7.3 (2013): 969-974.

[10] Maeda, Daichi, et al. "Glypican-3 expression in clear cell adenocarcinoma of the ovary." modern pathology 22.6 (2009): 824-832.

[11] Nakatsura, Tetsuya, et al. "Identification of glypican-3 as a novel tumor marker for melanoma." clinical cancer research 10.19 ( 2004): 6612-6621.

[12] Zhou, Fubo, et al. "Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment." medicinal research reviews 38.2 (2018): 741-767.

[13] Midorikawa, Yutaka, et al. "Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling. " International journal of cancer 103.4 (2003): 455-465.

[14] Nakano, Kiyotaka, et al. "Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells. "Biochemical and biophysical research communications 378.2 (2009): 279-284.

[15] Sung, Young Kwan, et al. "Glypican-3 is overexpressed in human hepatocellular carcinoma." cancer science 94.3 (2003): 259-262.

[16] Murthy, Siva S., et al. "Expression of GPC3, an X-linked recessive overgrowth gene, is silenced in malignant mesothelioma." Oncogene 19.3 (2000): 410-416.

[17] Peters, M. G., et al. "Inhibition of invasion and metastasis by glypican-3 in a syngeneic breast cancer model." Breast cancer research and treatment 80.2 (2003): 221-232.

[18] Lin, Qiang, et al. "Expression of GPC3 protein and its significance in lung squamous cell carcinoma." medical oncology 29.2 (2012) : 663-669.

[19] Li, B., et al. "Diagnostic value of glypican-3 in alpha fetoprotein negative hepatocellular carcinoma patients. "African health sciences 13.3 (2013): 703-709.

[20] Ning, Su, et al. "Glypican-3, a novel prognostic marker of hepatocellular cancer, is related with postoperative metastasis and recurrence in hepatocellular cancer patients." Molecular biology reports 39.1 (2012): 351-357.