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(1) Patients with severe cardiovascular and cerebrovascular, nervous system, blood system, immune system, digestive system diseases, chronic liver and kidney insufficiency, malignant tumors, and uncontrolled blood pressure and blood sugar;
(2) Segmentectomy, wedge resection or lobectomy, pneumonectomy, or lung volume reduction surgery (including bronchoscopy lung volume reduction surgery) due to COPD;
(3) Other concomitant active or clinically significant respiratory diseases that have a significant impact on the research: such as subjects with active pulmonary tuberculosis, bronchiectasis, pulmonary hypertension, pulmonary interstitial disease or other active pulmonary diseases;
(4) Those who use long-term oxygen therapy (oxygen therapy time > 15h/d) or mechanical ventilation;
(5) Those who have a history of mental illness, mental retardation, or inconvenience in movement, who could not be sedated and cooperated with the examination at that time;
(6) Those with coagulation dysfunction or severe skin damage and infection
(7) Pregnant or lactating women;
(8) Those who have metal implants in the body and suffer from claustrophobia and other contraindications to MRI examinations;
(9) Severe cranial anatomical structure asymmetry or clear lesions are found in MRI scans;
(10) Moderate constipation in the past 3 months (duration > In June, or < 6 months, but the symptoms of constipation are serious, conscious of pain, conservative treatment is ineffective or poor, seriously affect life) or moderate diarrhea (watery stool, 3~5 times within 24 hours, conscious of pain or interference with daily activities);
(11) Received drug treatment for cholecystitis, digestive tract ulcer, urinary tract infection, acute pyelonephritis, cystitis in the past 1 month;
(12) Antibiotics have been used in the past 3 months for 3 days or more;
(13) Those who participated in other clinical trials within the past 3 months or at the same time.
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