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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。 Cadein1 Cadein1 是一种异喹啉衍生物,在p53功能缺失的癌细胞中,可导致 G2/M 延迟和 caspase 依赖的凋亡。 ![]()
Cadein1 Chemical Structure 规格 是否有货 100 mg 询价 250 mg 询价 500 mg 询价
* Please select Quantity before adding items. 生物活性Cadein1, an isoquinolinium derivative, leads to a G2/M delay and caspase-dependent apoptosis in cancer cells with non- functional p53[1]. 体外研究(In Vitro)Cadein1 may be a potent anti-cancer agent against human cancers, specifically p53-deficient cancers with functional MMR[1]. Cadein1 activates p38 in p53-defective cancer cells with functional MMR to induce cell death. Cadein1 (4 μM) induces p38 phosphorylation in a time-dependent manner in HeLa and HCT116-Ch3/E6 cells [1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. 分子量655.64 FormulaC33H48F2INO2 运输条件Room temperature in continental US; may vary elsewhere. 储存方式Please store the product under the recommended conditions in the Certificate of Analysis. 参考文献[1]. Eun Ryoung Jang, et al. A new isoquinolinium derivative, Cadein1, preferentially induces apoptosis in p53-defective cancer cells with functional mismatch repair via a p38-dependent pathway. J Biol Chem. 2010 Jan 29;285(5):2986-95. 所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务 |
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