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功能概要
该基因编码的蛋白质是成纤维细胞生长因子 (FGF) 家族的成员。 FGF 家族成员具有广泛的促有丝分裂和细胞存活活性，并参与多种生物过程，包括胚胎发育、细胞生长、形态发生、组织修复、肿瘤生长和侵袭。这种蛋白质作为内皮细胞迁移和增殖的调节剂以及血管生成因子发挥作用。它在体外充当多种中胚层和神经外胚层衍生细胞的有丝分裂原，因此被认为参与器官发生。已经描述了编码不同亚型的多个可变剪接变体。[RefSeq 提供，2009 年 1 月]
The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]
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