G 蛋白信号调节器 1（RGS1）基因

该基因编码 G 蛋白信号家族的调节剂成员。这种蛋白质位于质膜的胞质侧，包含一个保守的 120 个氨基酸基序，称为 RGS 结构域。该蛋白通过与活化的、GTP 结合的 G α 亚基结合并充当 GTP 酶激活蛋白 (GAP) 来减弱 G 蛋白的信号活性，从而提高 GTP 向 GDP 的转化率。这种水解允许 G α 亚基结合 G β/γ 亚基异二聚体，形成无活性的 G 蛋白异三聚体，从而终止信号。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]